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A 42-year-old gentleman presents to the emergency department with complaints of fatigue, dizziness, and melena of 3 days duration. He denies any significant past medical history but has been taking ibuprofen 800 mg every 8 hours for a recent injury to his knee, sustained during a basketball game (he's a "weekend warrior"). Physical exam demonstrates a pale man with a temperature of 37° C, pulse 120, blood pressure 98/50, respirations 12. His abdomen is nontender and nondistended with active bowel sounds; there is no palpable organomegaly. His rectal exam demonstrates black stool that is heme-positive. The remainder of the exam is normal. His hemoglobin is 7.2 g/dL. You decide to transfuse him 2 units of packed red blood cells. After 30 minutes of transfusion, the patient complains of dyspnea and back pain. Repeat examination of this patient reveals a diaphoretic man with a pulse of 130 and blood pressure of 88/50. His lung fields are clear.