Objectives:

• Recognize hemolytic transfusion reactions
• Recognize late complications of blood transfusion
• Select appropriate dosing of blood products
• Generate differential diagnosis of dyspnea in a recently transfused patient

1		A 56-year-old male presents to the emergency department with an acute abdomen, likely from a perforated diverticulum. He is taking warfarin for a DVT that occurred after a total knee arthroplasty. He weighs 65 kg. You are evaluating him for surgery and find the following labs: Hgb 14.3 g/dl, platelets 478,000/mm3, INR 3.5, aPTT 28. Which of the following statements about his preoperative management is correct?
			A)	Platelet transfusion perioperatively will produce the most immediate reduction in risk of bleeding from warfarin.
			B)	FFP transfusion will produce the most immediate reduction in risk of bleeding from warfarin.
			C)	Vitamin K administration orally will produce the most immediate reduction in risk of bleeding from warfarin.
			D)	Vitamin K administration subcutaneously will produce the most immediate reduction in risk of bleeding from warfarin.
			E)	Cryoprecipitate transfusion will produce the most immediate reduction in risk of bleeding from warfarin.