A 9-month-old boy presents to clinic with his third episode of otitis media in the last 2 months. His other medical history includes pneumonia at the age of 7 months, for which he was hospitalized. Blood cultures at that time grew Haemophilus influenzae. His growth and physical development have been normal. Family history reveals a male cousin who died at age 14 months from pneumonia. On physical examination, there is no lymphadenopathy, and tonsillar tissue is not visualized. He has a bulging, erythematous tympanic membrane on the left. Lungs and remainder of physical examination are normal. You suspect immune deficiency and perform extensive laboratory workup. Flow cytometry reveals few circulating B-lymphocytes.

1		What is the most likely diagnosis?
			A)	Leukocyte adhesion deficiency.
			B)	X-linked agammaglobulinemia.
			C)	DiGeorge’s syndrome.
			D)	Chediak-Higashi syndrome.
			E)	Severe combined immunodeficiency disease.
2		You decide to treat this patient. You initiate IVIG. All of the following are major complications of IVIG therapy EXCEPT:
			A)	Renal failure.
			B)	Anaphylaxis.
			C)	Cholestasis.
			D)	Myocardial infarction.
			E)	Thromboembolic disease.
3		Which of the following patients is most likely to develop an anaphylactic reaction in response to the administration of IVIG?
			A)	A patient with IgA deficiency.
			B)	A patient with IgG deficiency.
			C)	A patient with sickle-cell anemia.
			D)	A patient with graft versus host disease.
			E)	A pregnant patient.