Site MapHelpFeedbackPractice Problems
Practice Problems
(See related pages)



1

The substituent X in an acid derivative R-C(O)X increases the stability of the carbonyl group when it is?
A)highly electronegative
B)not very electronegative
2

The most reactive type of compound to a nucleophilic attack on the carbonyl group is?
A)an acid
B)an amide
C)an anhydride
D)an acyl chloride
E)an ester
3

The least reactive type of compound to a nucleophilic attack is?
A)an acid
B)an amide
C)an anhydride
D)an acyl chloride
E)an ester
4

The greater reactivity of acyl chlorides over alkyl chlorides to nucleophilic substitution reactions is due to?
A)the sp2 hybridized carbon of the acyl halide is less sterically hinder
B)the sp2 hybridized carbon of the acyl halide is more sterically hinder
C)the acyl halide has a lower energy transition state.
D)the acyl halide has a higher energy transition state.
E)A and C
F)A and D
G)B and C
H)B and D
5

The product of the hydrolysis of an acyl chloride is?
A)an acid
B)an amide
C)an anhydride
D)an aldehyde
E)an ester
6

The product of mixing an acyl halide and an acid is?
A)an acid
B)an amide
C)an anhydride
D)an aldehyde
E)an ester
7

In the acid catalyzed hydrolysis of an ester (R-C(O)-OR') the first step of the reaction is?
A)loss of the oxide (R'-O-).
B)protonation of the carbonyl oxygen atom.
C)protonation of the ether oxygen atom.
D)nucleophilic attack of a water molecule on the carbonyl carbon atom.
E)loss of the leaving group (R'-OH).
8

In contrast to the acid catalyzed hydrolysis of an ester, the based catalyzed reaction is?
A)reversible
B)irreversible
9

Amides are commonly prepared by reacting acyl halides, esters, or anhydrides with?
A)ammonium hydroxide.
B)ammonium chloride.
C)ammonia.
D)tertiary amines.
E)quarternary ammonium salts.
10

Lactams are?
A)cyclic acids.
B)cyclic esters.
C)cyclic amines.
D)cyclic anhydrides.
E)cyclic amides.
11

Nitriles can be prepared by?
A)the hydration of amines.
B)the dehydration of acids.
C)the reduction of acids.
D)the dehydration of amides.
E)the oxidation of amides.
12

The conversion of a nitrile to an acid is achieved by?
A)an oxidation.
B)a reduction.
C)a dehydration.
D)a substitution.
E)a hydrolysis.
13

The final product of the reaction of a nitrile and a Grignard reagent is?
A)an acid.
B)an aldehyde.
C)an amine.
D)an imine.
E)a ketone.





To learn more about the book this website supports, please visit its Information Center.
(c)2006 McGraw-Hill Higher Education
Any use is subject to the Terms of Use and Privacy Policy.
McGraw-Hill Higher Education is one of the many fine businesses of The McGraw-Hill Companies.


Organic ChemistryOnline Learning Center

Home > Chapter 20 > Practice Problems