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Harrison's: Principles of Internal Medicine, 2/e
Dennis L. Kasper Eugene Braunwald Anthony S. Fauci Stephen L. Hauser Dan L. Longo J. Larry Jameson
ISBN: 0071402357Copyright year: 2005
Table of Contents PART ONE — INTRODUCTION TO CLINICAL MEDICINE
The Practice of Medicine — The EditorsDecision-Making in Clinical Medicine — Daniel B. MarkPrinciples of Clinical Pharmacology — Dan M. RodenScreening and Prevention of Disease — Gary J. MartinWomen's Health — Andrea DunaifMedical Disorders During Pregnancy — Robert L. Barbieri/ John T. Repke Medical Evaluation of the Surgical Patient — Gerald W. SmetanaGeriatric Medicine — Neil M. Resnick / David DosaPalliative and End-of-Life Care — Ezekiel J. Emanuel / Linda L. EmanuelComplementary and Alternative Medicine — Stephen E. StrausGo To Top PART TWO — CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES
Section 1: Pain Pain: Pathophysiology and Management — Howard L. Fields/Joseph B. MartinChest Discomfort and Palpitations — Thomas H. LeeAbdominal Pain — William SilenHeadache — Neil H. RaskinBack and Neck Pain — John W. EngstromSection 2: Alterations in Body Temperature Fever and Hyperthermia — Charles A. Dinarello/Jeffrey A. GelfandFever and Rash — Elaine T. Kaye/Kenneth M. KayeFever of Unknown Origin — Jeffrey A. Gelfand/Michael V. CallahanHypothermia and Frostbite — Daniel F. DanzlSection 3: Nervous System Dysfunction Syncope, Faintness, Dizziness, and Vertigo — Robert B. Daroff/Mark D. CarlsonWeakness, Disorders of Movement, and Imbalance — Richard K. OlneyNumbness, Tingling, and Sensory Loss — Arthur K. AsburyAphasia, Memory Loss, and Other Focal Cerebral Disorders — M-Marsel MesulamSleep Disorders — Charles A. Czeisler/John W. Winkelman/Gary S. RichardsonSection 4: Disorders of Eyes, Ears, Nose, and Throat Disorders of the Eye — Jonathan C. HortonDisorders of Smell, Taste, and Hearing — Anil K. Lalwani/James B. Snow, Jr.Infections of the Upper Respiratory Tract — Michael A. Rubin/Ralph Gonzales/Merle A. SandeOral Manifestations of Disease — Samuel C. DursoSection 5: Alterations in Circulatory and Respiratory Functions Dyspnea and Pulmonary Edema — Roland H. Ingram, Jr./Eugene BraunwaldCough and Hemoptysis — Steven E. WeinbergerHypoxia and Cyanosis — Eugene BraunwaldEdema — Eugene BraunwaldSection 6: Alterations in Gastrointestinal Function Dysphagia — Raj K. GoyalNausea, Vomiting, and Indigestion — William L. HaslerDiarrhea and Constipation — David A. Ahlquist/Michael CamilleriWeight Loss — Carol M. ReifeGastrointestinal Bleeding — Loren LaineJaundice — Daniel S. Pratt/Marshall M. KaplanAbdominal Swelling and Ascites — Robert M. GlickmanSection 7: Alterations in Renal and Urinary Tract Function Azotemia and Urinary Abnormalities — Bradley M. Denker/Barry M. BrennerFluid and Electrolyte Disturbances — Gary G. Singer/Barry M. BrennerAcidosis and Alkalosis — Thomas D. DuBose, Jr.Section 8: Alterations in Sexual Function and Reproduction Sexual Dysfunction — Kevin T. McVaryHirsutism and Virilization — David A. EhrmannInfertility and Fertility Control — Janet E. HallSection 9: Alterations in the Skin Approach to the Patient with a Skin Disorder — Thomas J. Lawley/Kim B. YanceyEczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders — Calvin O. McCall/Thomas J. LawleySkin Manifestations of Internal Disease — Jean L. Bolognia/Irwin M. BravermanImmunologically Mediated Skin Diseases — Kim B. Yancey/Thomas J. LawleyCutaneous Drug Reactions — Olivier M. Chosidow/Robert S. Stern/ Bruce U. WintroubPhotosensitivity and Other Reactions to Light — David R. BickersSection 10: Hematologic Alterations Anemia and Polycythemia — John W. Adamson/Dan L. LongoBleeding and Thrombosis — Robert I. HandinEnlargement of Lymph Nodes and Spleen — Patrick H. Henry/Dan L. LongoDisorders of Granulocytes and Monocytes — Steven M. Holland/John I. GallinGo To Top PART THREE — GENETICS AND DISEASE
Principles of Human Genetics — J. Larry Jameson/Peter KoppChromosome Disorders — Terry Hassold/Stuart SchwartzThe Practice of Genetics in Clinical Medicine — Susan Miesfeldt/J. Larry JamesonStem Cell and Gene Transfer in Clinical Medicine — David Bodine/J. Larry Jameson/Ron McKayGo To Top PART FOUR — NUTRITION
Nutritional Requirements and Dietary Assessment — Johanna DwyerVitamin and Trace Mineral Deficiency and Excess — Robert M. RussellMalnutrition and Nutritional Assessment — Charles H. HalstedEnteral and Parenteral Nutrition Therapy — Lyn HowardObesity — Jeffrey S. Flier/Eleftheria Maratos-FlierEating Disorders — B. Timothy WalshGo To Top PART FIVE — ONCOLOGY AND HEMATOLOGY
Section 1: Neoplastic Disorders Approach to the Patient with Cancer — Dan L. LongoPrevention and Early Detection of Cancer — Otis W. Brawley/Barnett S. KramerCancer Genetics — Patrice J. Morin/Jeffrey M. Trent/Francis S. Collins/Bert VogelsteinCancer Biology and Angiogenesis — Robert G. Fenton/Dan L. LongoPrinciples of Cancer Treatment: Surgery, Chemotherapy, and Biologic Therapy — Edward A. Sausville/Dan L. LongoPrinciples of Radiation Therapy — Stephen M. Hahn/Eli GlatsteinInfections in Patients with Cancer — Robert FinbergCancer of the Skin — Katarina G. Chiller/Carl Washington/Arthur J. Sober/Howard K. KohHead and Neck Cancer — Everett E. VokesNeoplasms of the Lung — John D. MinnaBreast Cancer — Marc E. LippmanGastrointestinal Tract Cancer — Robert J. MayerTumors of the Liver and Biliary Tract — Jules L. Dienstag/Kurt J. IsselbacherPancreatic Cancer — Robert J. MayerBladder and Renal Cell Carcinomas — Howard I. Scher/Robert J. MotzerHyperplastic and Malignant Diseases of the Prostate — Howard I. ScherTesticular Cancer — Robert J. Motzer/George J. BoslGynecologic Malignancies — Robert C. YoungSoft Tissue and Bone Sarcomas and Bone Metastases — Shreyaskumar R. Patel/Robert S. BenjaminMetastatic Cancer of Unknown Primary Site — Richard M. StoneParaneoplastic Syndromes: Endocrinologic/Hematologic — J. Larry Jameson/Bruce E. JohnsonParaneoplastic Neurologic Syndromes — Josep Dalmau/Myrna R. RosenfeldOncologic Emergencies — Rasim Gucalp/Janice DutcherLate Consequences of Cancer and Its Treatment — Michael C. Perry/Dan L. LongoSection 2: Hematopoietic Disorders Iron Deficiency and Other Hypoproliferative — John W. AdamsonAnemias Hemoglobinopathies — Edward J. BenzMegaloblastic Anemias — Bernard M. Babior/H. Franklin BunnHemolytic Anemias and Acute Blood Loss — H. Franklin Bunn/Wendell RosseAplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes — Neal S. YoungPolycythemia Vera and Other Myeloproliferative Diseases — Jerry L. SpivakAcute and Chronic Myeloid Leukemia — Meir Wetzler/John C. Byrd/Clara D. BloomfieldMalignancies of Lymphoid Cells — James O. Armitage/Dan L. LongoPlasma Cell Disorders — Dan L. Longo/Kenneth C. AndersonTransfusion Biology and Therapy — Jeffery S. Dzieczkowski/Kenneth C. AndersonHematopoietic Cell Transplantation — Frederick R. AppelbaumSection 3: Disorders of Hemostasis Disorders of the Platelet and Vessel Wall — Robert I. HandinDisorders of Coagulation and Thrombosis — Robert I. HandinAntiplatelet, Anticoagulant, and Fibrinolytic Therapy — Steven R. DeitcherGo To Top PART SIX — INFECTIOUS DISEASES
Section 1: Basic Considerations in Infectious Diseases
>Introduction to Infectious Diseases: Host-Pathogen Interactions — Lawrence C. Madoff/Dennis L. KasperMolecular Mechanisms of Microbial Pathogenesis — Gerald B. PierApproach to the Acutely Ill Infected Febrile Patient — Tamar F. Barlam/Dennis L. KasperImmunization Principles and Vaccine Use — Gerald T. Keusch/Kenneth J. Bart/Mark MillerHealth Advice for International Travel — J.S. Keystone/P.E. Kozarsky Section 2: Clinical Syndromes: Community-Acquired Infections Infective Endocarditis — Adolf W. KarchmerInfections of the Skin, Muscle, and Soft Tissues — Dennis L. StevensOsteomyelitis — Jeffrey Parsonnet/James H. MaguireIntraabdominal Infections and Abscesses — Dennis L. Kasper/Dori F. ZaleznikAcute Infectious Diarrheal Diseases and Bacterial Food Poisoning — Joan R. Butterton/Stephen B. CalderwoodClostridium difficile - Associated Disease, Including Pseudomembranous Colitis — Dale N. Gerding/Stuart JohnsonSexually Transmitted Diseases: Overview and Clinical Approach — King K. HolmesSection 3: Clinical Syndromes: Nosocomial Infections Hospital-Acquired Infections — Robert A. WeinsteinInfections in Transplant Recipients — Robert Finberg/Joyce FingerothSection 4: Approach to Therapy for Bacterial Diseases Treatment and Prophylaxis of Bacterial Infections — Gordon L. Archer/Ronald E. PolkSection 5: Diseases Caused by Gram-Positive Bacteria Pneumococcal Infections — Daniel M. MusherStaphylococcal Infections — Franklin D. LowyStreptococcal and Enterococcal Infections — Michael R. WesselsDiphtheria and Other Corynebacterial Infections — Randall K. HolmesInfections Caused by Listeria monocytogenes — Anne Schuchat/Claire V. BroomeTetanus — Elias AbrutynBotulism — Elias AbrutynGas Gangrene and Other Clostridial Infections — Dennis L. Kasper/Lawrence C. MadoffSection 6: Diseases Caused by Gram-Negative Bacteria Meningococcal Infections — David Stephens/Robert S. Munford/Lee M. WetzlerGonococcal Infections — Sanjay Ram/Peter A. RiceMoraxella catarrhalis and Other Moraxella Species — Daniel M. MusherHaemophilus Infections — Timothy F. MurphyInfections due to the HACEK Group and Miscellaneous Gram-Negative Bacteria — Dennis L. Kasper/Tamar F. BarlamLegionella Infection — Feng-Yee Chang/Victor L. YuPertussis and Other Bordetella Infections — Scott A. HalperinDiseases Caused by Gram-Negative Enteric Bacilli — Thomas A. RussoHelicobacter pylori Infections — John C. Atherton/Martin J. BlaserInfections Due to Pseudomonas Species and Related Organisms — Christopher A. Ohl/Matthew PollackSalmonellosis — Cammie F. Lesser/Samuel I. MillerShigellosis — Gerald T. Keusch/Dennis J. KopeckoInfections Due to Campylobacter and Related Species — Martin J. BlaserCholera and Other Vibrioses — Matthew K. Waldor/Gerald T. KeuschBrucellosis — Michael J. Corbel/Nicholas J. BeechingTularemia — Richard F. JacobsPlague and Other Yersinia Infections — David T. Dennis/Grant L. CampbellBartonella Infections, Including Cat-Scratch Disease — Lucy Stuart TompkinsDonovanosis — Gavin HartSection 7: Miscellaneous Bacterial Infections Nocardiosis — Gregory A. FiliceActinomycosis — Thomas A. RussoInfections due to Mixed Anaerobic Organisms — Dennis L. KasperSection 8: Mycobacterial Diseases Antimycobacterial Agents — Richard J. Wallace, Jr./Donald E. GriffinTuberculosis — Mario C. Raviglione/Richard J. O'BrienLeprosy (Hansen's Disease) — Robert H. GelberNontuberculous Mycobacteria — C. Fordham von ReynSection 9: Spirochetal Diseases Syphilis — Sheila A. LukehartEndemic Treponematoses — Sheila A. LukehartLeptospirosis — Peter SpeelmanRelapsing Fever — David T. Dennis/Edward B. HayesLyme Borreliosis — Allen C. SteereSection 10: Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia Rickettsial Diseases — David Walker/Didier Raoult/J. Stephen Dumler/Thomas MarrieInfections Due to Mycoplasmas — William M. McCormackChlamydial Infections — Walter E. StammSection 11: Viral Diseases: General Considerations Medical Virology — Fred Wang/Elliott KieffAntiviral Chemotherapy, Excluding Antiretroviral Drugs — Lindsey R. Baden/Raphael DolinSection 12: Infections Due to DNA Viruses Herpes Simplex Viruses — Lawrence CoreyVaricella-Zoster Virus Infections — Richard J. WhitleyEpstein-Barr Virus Infections, Including Infectious Mononucleosis — Jeffrey I. CohenCytomegalovirus and Human Herpesvirus Types 6, 7, and 8 — Martin S. HirschMolluscum contagiosum and Other Poxviruses, Excluding Smallpox Virus — Fred WangParvovirus — Neil R. BlacklowHuman Papillomavirus Infections — Richard C. ReichmanSection 13: Infections Due to DNA and RNA Respiratory Viruses Common Viral Respiratory Infections & Severe Acute Respiratory Syndrome — Raphael DolinInfluenza — Raphael DolinSection 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses The Human Retroviruses — Dan L. Longo/Anthony S. FauciHuman Immunodeficiency Disease: AIDS and Related Disorders — Anthony S. Fauci/H. Clifford LaneSection 15: Infections Due to RNA Viruses Viral Gastroenteritis — Umesh D. Parashar/Roger I. GlassEnteroviruses and Reoviruses — Jeffrey I. CohenMeasles (Rubeola) — Anne GershonRubella (German Measles) — Anne GershonMumps — Anne GershonRabies Virus and Other Rhabdoviruses — Cathleen A. Hanlon/Lawrence CoreyInfections Caused by Arthropod- and Rodent-Borne Viruses — Clarence J. PetersEbola and Marburg Viruses — Clarence J. PetersSection 16: Fungal and Algal Infections Diagnosis and Treatment of Fungal Infection — John E. BennettHistoplasmosis — John E. BennettCoccidioidomycosis — John E. BennettBlastomycosis — John E. BennettCryptococcosis — John E. BennettCandidiasis — John E. BennettAspergillosis — John E. BennettMucormycosis — John E. BennettMiscellaneous Mycoses and Algal Infections — John E. BennettPneumocystis Infection — Peter D. WalzerSection 17: Protozoal and Helminthic Infections: General Considerations Laboratory Diagnosis of Parasitic Infections — Charles E. DavisAgents Used to Treat Infections Due to Parasites and Pneumocystis — Thomas A. MooreSection 18: Protozoal Infections Amebiasis and Infection with Free-Living Amebas — Sharon L. ReedMalaria and Babesiosis: Diseases Caused by Red Blood Cell Parasites — Nicholas J. White/Joel G. BremanLeishmaniasis — Barbara L. HerwaldtTrypanosomiasis — Louis V. KirchhoffToxoplasma Infection — Lloyd H. KasperProtozoal Intestinal Infections and Trichomoniasis — Peter F. WellerSection 19: Helminthic Infections Trichinella and Other Tissue Nematodes — Peter F. WellerIntestinal Nematodes — Peter F. Weller/Thomas B. NutmanFilarial and Related Infections — Thomas B. Nutman/Peter F. WellerSchistosomiasis and Other Trematode Infections — Adel A.F. MahmoudCestodes — A. Clinton White, Jr./Peter F. WellerGo To Top PART SEVEN — BIOTERRORISM AND CLINICAL MEDICINE
Microbial Terrorism — H. Clifford Lane/Anthony S. FauciChemical Bioterrorism — Charles G. Hurst/Jonathan Newmark/James A. RomanoRadiation Bioterrorism — Zelig A. Tochner/Ofer Lehavi/Eli GlatsteinGo To Top PART EIGHT — DISORDERS OF THE CARDIOVASCULAR SYSTEM
Section 1: Diagnosis of Cardiovascular Disorders Approach to the Patient with Cardiovascular Disease — Eugene BraunwaldPhysical Examination of the Cardiovascular System — Robert A. O'Rourke/Eugene BraunwaldElectrocardiography — Ary L. GoldbergerNoninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging — Rick A. Nishimura/Raymond J. Gibbons/James F. Glockner/A. Jamil TajikDiagnostic Cardiac Catheterization and Angiography — Donald S. Baim/William GrossmanSection 2: Disorders of Rhythm The Bradyarrhythmias: Disorders of Sinus Node Function and AV Conduction Disturbances AV Conduction Disturbances — Mark E. Josephson/Peter ZimetbaumThe Tachyarrhythmias — Mark E. Josephson/Peter ZimetbaumSection 3: Disorders of the Heart Normal and Abnormal Myocardial Function — Eugene BraunwaldHeart Failure and Cor Pulmonale — Eugene BraunwaldCardiac Transplantation and Prolonged Assisted Circulation — Sharon A. HuntCongenital Heart Disease in the Adult — John S. Child/William F. FriedmanValvular Heart Disease — Eugene BraunwaldPulmonary Hypertension — Stuart RichCardiomyopathy and Myocarditis — Joshua Wynne/Eugene BraunwaldPericardial Disease — Eugene BraunwaldCardiac Tumors, Cardiac Manifestations of Systemic Diseases and Traumatic Cardiac Injury — Wilson S. Colucci/Daniel T. PriceSection 4: Vascular Disease The Pathogenesis of Atherosclerosis — Peter LibbyPrevention and Treatment of Atherosclerosis — Peter LibbyIschemic Heart Disease — Andrew P. Selwyn/Eugene BraunwaldUnstable Angina and Non-ST-Elevation Myocardial Infarction — Christopher P. Cannon/Eugene BraunwaldST-Segment Elevation Myocardial Infarction — Elliott M. Antman/Eugene BraunwaldPercutaneous Coronary Revascularization — Donald S. BaimHypertensive Vascular Disease — Naomi D.L. Fisher/Gordon H. WilliamsDiseases of the Aorta — Victor J. Dzau/Mark A. CreagerVascular Diseases of the Extremities — Mark A. Creager/Victor J. DzauGo To Top PART NINE — DISORDERS OF THE RESPIRATORY SYSTEM
Section 1: Diagnosis of Respiratory Disorders Approach to the Patient with Disease of the Respiratory System — Jeffrey M. Drazen/ Steven E. WeinbergerDisturbances of Respiratory Function — Steven E. Weinberger/ Jeffrey M. DrazenDiagnostic Procedures in Respiratory Disease — Steven E. Weinberger/ Jeffrey M. DrazenSection 2: Diseases of the Respiratory System Asthma — E.R. McFadden, Jr.Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia — Joel N. Kline/Gary W. HunninghakeEnvironmental Lung Diseases — Frank E. SpeizerPneumonia — Thomas J. Marrie/G. Douglas Campbell/David H. Walker/Donald E. LowBronchiectasis — Steven E WeinbergerCystic Fibrosis — Richard C. BoucherChronic Obstructive Pulmonary Disease — John J. Reilly/Edwin K. Silverman/Steven D. ShapiroInterstitial Lung Diseases — Talmadge E. King, Jr.Pulmonary Thromboembolism — Samuel Z. GoldhaberDisorders of the Pleura, Mediastinum, Diaphragm, and Chest Wall — Richard W. LightDisorders of Ventilation — Eliot A. PhillipsonSleep Apnea — Eliot A. PhillipsonLung Transplantation — Elbert P. Trulock/ G. Alexander Patterson/Joel D. CooperGo To Top PART TEN — CRITICAL CARE MEDICINE
Section 1: Respiratory Critical Care Principles of Critical Care Medicine — John P. Kress/Jesse B. HallRespiratory Failure — Craig Lilly/Edward P. Ingenito/Steven D. ShapiroAcute Respiratory Distress Syndrome — Bruce D. Levy/Steven D. ShapiroMechanical Ventilatory Support — Edward P. Ingenito/Jeffrey M. DrazenSection 2: Shock and Cardiac Arrest Approach to the Patient with Shock — Ronald V. MaierSevere Sepsis and Septic Shock — Robert S. MunfordCardiogenic Shock and Pulmonary Edema — Judith S. Hochman/David IngbarCardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death — Robert J. Myerburg/Agustin CastellanosSection 3: Neurologic Critical Care Acute Confusional States and Coma — Allan H. RopperCritical Care Neurology — J. Claude HemphillGo To Top PART ELEVEN — DISORDERS OF THE KIDNEY AND URINARY TRACT
Adaptation to Renal Injury — Robert M. Brenner/ Barry M. BrennerAcute Renal Failure — Hugh R. Brady/ Barry M. BrennerChronic Renal Failure — Karl Skorecki/Jacob Green/Barry M. BrennerDialysis in the Treatment of Renal Failure — Ajay K. Singh/Barry M. BrennerTransplantation in the Treatment of Renal Failure — Charles B. Carpenter/Edgar L. Milford/Mohamed H. SayeghGlomerular Diseases — Hugh R. Brady/Yvonne M. O'Meara/Barry M. BrennerTubular Disorders — John R. Asplin/Fredric L. CoeTubulointerstitial Diseases of the Kidney — Alan S. L. Yu/Barry M. BrennerVascular Injury to the Kidney — Kamal F. Badr/Barry M. BrennerNephrolithiasis — John R. Asplin/Fredric L. Coe/Murray J. FavusUrinary Tract Infections and Pyelonephritis — Walter E. StammUrinary Tract Obstruction — Julian L. Seifter/Barry M. BrennerGo To Top PART TWELVE — DISORDERS OF THE GASTROINTESTINAL SYSTEM
Section 1: Disorders of the Alimentary Tract Approach to the Patient with Gastrointestinal Disease — William L. Hasler/Chung OwyangGastrointestinal Endoscopy — Mark TopazianDiseases of the Esophagus — Raj K. GoyalPeptic Ulcer Disease and Related Disorders — John Del ValleDisorders of Absorption — Henry J. BinderInflammatory Bowel Disease — Sonia Friedman/Richard S. BlumbergIrritable Bowel Syndrome — Chung OwyangFamilial Mediterranean Fever and Other Hereditary Recurrent Fevers — Daniel L. KastnerCommon Diseases of the Colon and Anorectum and Mesenteric Vascular Insufficiency — L. Gearhart/Gregory BulkleyAcute Intestinal Obstruction — William SilenAcute Appendicitis and Peritonitis — William SilenSection 2: Liver and Biliary Tract Disease Approach to the Patient with Liver Disease — Marc Ghany/Jay H. HoofnagleEvaluation of Liver Function — Daniel S. Pratt/Marshall M. KaplanThe Hyperbilirubinemias — Allan W. WolkoffAcute Viral Hepatitis — Jules L. Dienstag/Kurt J. IsselbacherToxic and Drug-Induced Hepatitis — Jules L. Dienstag/Kurt J. IsselbacherChronic Hepatitis — Jules L. Dienstag/Kurt J. IsselbacherAlcoholic Liver Disease — Mark E. Milliard/Michael F. SorrellCirrhosis and Its Complications — Raymond T. Chung/Daniel K. PodolskyInfiltrative, Genetic, and Metabolic Diseases Affecting the Liver — Daniel K PodolskyLiver Transplantation — Jules L. DienstagDiseases of the Gallbladder and Bile Ducts — Norton J. Greenberger/Gustav PaumgartnerSection 3: Disorders of the Pancreas Approach to the Patient with Pancreatic Disease — Phillip P. Toskes/Norton J. GreenbergerAcute and Chronic Pancreatitis — Norton J. Greenberger/Phillip P. ToskesGo To Top PART THIRTEEN — DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS
Section 1: The Immune System in Health and Disease Introduction to the Immune System — Barton F. Haynes/Anthony S. FauciThe Major Histocompatibility Gene Complex — Gerald T. Nepom/Joel D. TaurogPrimary Immune Deficiency Diseases — Max D. Cooper/Harry W. Schroeder, Jr.Section 2: Disorders of Immune-Mediated Injury Allergies, Anaphylaxis, and Systemic Mastocytosis — K. Frank AustenAutoimmunity and Autoimmune Diseases — Peter E. Lipsky/Betty DiamondSystemic Lupus Erythematosus — Bevra Hannahs HahnRheumatoid Arthritis — Peter E. LipskyRheumatic Fever — Edward L. KaplanSystemic Sclerosis (Scleroderma) and Related Disorders — Bruce C. GillilandSjögren's Syndrome — Haralampos M. MoutsopoulosThe Spondyloarthritidies — Joel D. TaurogThe Vasculitis Syndromes — Michael C. Sneller/Carol A. Langford/Anthony S. FauciBehçet's Syndrome — Haralampos M. MoutsopoulosRelapsing Polychondritis — Bruce C. GillilandSarcoidosis — Ronald G. CrystalAmyloidosis — Jean D. Sipe/Alan S. CohenSection 3: Disorders of the Joints and Adjacent Tissues Approach to Articular and Musculoskeletal Disorders — John J. Cush/Peter E. LipskyOsteoarthritis — Kenneth D. BrandtGout and Other Crystal Arthropathies — Antonio J. ReginatoInfectious Arthritis — Lawrence C. Madoff/Scott J. Thaler/James H. MaguireFibromyalgia, Arthritis Associated with Systemic Diseases, and Other Arthritides — Bruce C. GillilandPeriarticular Disorders of the Extremities — Bruce C. GillilandGo To Top PART FOURTEEN — ENDOCRINOLOGY AND METABOLISM
Section 1: Endocrinology Principles of Endocrinology — J. Larry JamesonDisorders of the Anterior Pituitary and Hypothalamus — Shlomo Melmed/J. Larry JamesonDisorders of the Neurohypophysis — Gary L. RobertsonDiseases of the Thyroid Gland — J. Larry Jameson/Anthony P. WeetmanDisorders of the Adrenal Cortex — Gordon H. Williams/Robert G. DluhyPheochromocytoma vLewis Landsberg/James B. YoungDiabetes Mellitus — Alvin C. PowersHypoglycemia — Philip E. CryerDisorders of the Testes and Male Reproductive System — Shalendar Bhasin/J. Larry JamesonDisorders of the Ovary and Female Reproductive Tract — Bruce R. Carr/Karen D. BradshawThe Menopause Transition and Postmenopausal Hormone Therapy — JoAnn E. Manson/Shari S. BassukDisorders of Sexual Differentiation — John C. Achermann/J. Larry JamesonEndocrine Tumors of the Gastrointestinal Tract and Pancreas — Robert T. JensenDisorders Affecting Multiple Endocrine Systems — Steven I. Sherman/Robert F. GagelSection 2: Disorders of Bone and Mineral Metabolism Bone and Mineral Metabolism in Health and Disease — F. Richard Bringhurst/Marie B. Demay/Stephen M. Krane/Henry M. KronenbergDiseases of the Parathyroid Gland and Other Hyper- and Hypocalcemic Disorders — John T. Potts, Jr.Osteoporosis — Robert Lindsay/Felicia CosmanPaget Disease and Other Dysplasias of Bone — Murray J. Favus/Tamara J. VokesSection 3: Disorders of Intermediary Metabolism Disorders of Lipoprotein Metabolism — Daniel J. Rader/Helen H. HobbsHemochromatosis — Lawrie W. PowellThe Porphyrias — Robert J. DesnickDisorders of Purine and Pyrimidine Metabolism — Robert L. WortmannWilson Disease — George J. BrewerLysosomal Storage Diseases — Robert J. Hopkin/Gregory A. GrabowskiGlycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism — Yuan-Tsong ChenInherited Disorders of Connective Tissue — Darwin J. Prockop/Leena Ala-KokkoInherited Disorders of Amino Acid Metabolism Presenting in Adults — Nicola LongoInherited Defects of Membrane Transport — Nicola LongoGo To Top PART FIFTEEN — NEUROLOGIC DISORDERS
Section 1: Diagnosis of Neurologic Disorders Neurobiology of Disease — Stephen L. Hauser/M. Flint BealApproach to the Patient with Neurologic Disease — Joseph B. Martin/Daniel H. Lowenstein/Stephen L. HauserNeuroimaging in Neurologic Disorders — William P. DillonSection 2: Diseases of the Central Nervous System Seizures and Epilepsy — Daniel H. LowensteinCerebrovascular Diseases — Wade S. Smith/S. Claiborne Johnston/J. Donald EastonAlzeimer's Disease and Other Dementias — Thomas D. Bird/Bruce L. MillerParkinson's Disease and Other Movement Disorders — Mahlon R. DeLong/Jorge L. JuncosAtaxic Disorders — Roger N. RosenbergAmyotrophic Lateral Sclerosis and Other Motor Neuron Diseases — Robert H. Brown, Jr.Disorders of the Autonomic Nervous System — Phillip A. Low/John W. EngstromTrigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders — M. Flint Beal/Stephen L. HauserDiseases of the Spinal Cord — Stephen L. Hauser/Allan H. RopperConcussion and Other Head Injuries — Allan H. RopperPrimary and Metastatic Tumors of the Nervous System — Stephen M. Sagar/Mark A. IsraelMultiple Sclerosis and Other Demyelinating Diseases — Stephen L. Hauser/Douglas S. GoodeMeningitis, Encephalitis, Brain Abscess, and Empyema — Karen L. Roos/Kenneth L. TylerChronic and Recurrent Meningitis Walter J. Koroshetz/Morton N. SwartzPrion Diseases — Stanley B. Prusiner/Bruce MillerSection 3: Disorders of Nerves and Muscles Approach to the Patient with Peripheral Neuropathy — Arthur K. AsburyCharcot-Marie-Tooth Disease and Other Inherited Neuropathies — Philip F. Chance/Thomas D. BirdGuillain-Barré Syndrome and Other Immune-Mediated Neuropathies — Stephen L. Hauser/Arthur K. AsburyMyasthenia Gravis and Other Diseases of the Neuromuscular Junction — Daniel B. DrachmanApproach to the Patient with Muscle Disease — Jerry R. MendellMuscular Dystrophies and Other Muscle Diseases — Robert H. Brown, Jr./Jerry R. MendellPolymyositis, Dermatomyositis, and Inclusion Body Myositis — Marinos C. DalakasSection 4: Chronic Fatigue Syndrome Chronic Fatigue Syndrome — Stephen E. StrausSection 5: Psychiatric Disorders Mental Disorders — Victor I. ReusSection 6: Alcoholism and Drug Dependency Alcohol and Alcoholism — Marc A. SchuckitOpioid Drug Abuse and Dependence — Marc A. Schuckit/David S. SegalCocaine and Other Commonly Abused Drugs — Jack H. Mendelson/Nancy K. MelloNicotine Addiction — David M. BurnsGo To Top PART SIXTEEN — POISONING, DRUG OVERDOSE, AND ENVENOMATION
Heavy Metal Poisoning — Howard HuPoisoning and Drug Overdosage — Christopher H. Linden/Michael J. BurnsDisorders Caused by Reptile Bites and Marine Animal Exposures — Paul S. Auerbach/Robert L. NorrisEctoparasite Infestations and Arthropod Bites and Stings — James H. Maguire/Richard J. Pollack/Andrew SpielmanAppendices: Laboratory Values of Clinical Importance — Alexander Kratz/Patrick M. Sluss/James L. Januzzi, Jr./Kent B. Lewandrowski