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Harrison's: Principles of Internal Medicine, 2/e

Dennis L. Kasper
Eugene Braunwald
Anthony S. Fauci
Stephen L. Hauser
Dan L. Longo
J. Larry Jameson

ISBN: 0071402357
Copyright year: 2005

Table of Contents



PART 1INTRODUCTION TO CLINICAL MEDICINE
PART 2CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES
PART 3GENETICS AND DISEASE
PART 4NUTRITION
PART 5ONCOLOGY AND HEMATOLOGY
PART 6INFECTIOUS DISEASES
PART 7BIOTERRORISM AND CLINICAL MEDICINE
PART 8DISORDERS OF THE CARDIOVASCULAR SYSTEM
PART 9DISORDERS OF THE RESPIRATORY SYSTEM
PART 10CRITICAL CARE MEDICINE
PART 11DISORDERS OF THE KIDNEY AND URINARY TRACT
PART 12DISORDERS OF THE GASTROINTESTINAL SYSTEM
PART 13DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS
PART 14ENDOCRINOLOGY AND METABOLISM
PART 15NEUROLOGIC DISORDERS
PART 16POISONING, DRUG OVERDOSE, AND ENVENOMATION


PART ONE — INTRODUCTION TO CLINICAL MEDICINE

  1. The Practice of Medicine — The Editors
  2. Decision-Making in Clinical Medicine — Daniel B. Mark
  3. Principles of Clinical Pharmacology — Dan M. Roden
  4. Screening and Prevention of Disease — Gary J. Martin
  5. Women's Health — Andrea Dunaif
  6. Medical Disorders During Pregnancy — Robert L. Barbieri/ John T. Repke
  7. Medical Evaluation of the Surgical Patient — Gerald W. Smetana
  8. Geriatric Medicine — Neil M. Resnick / David Dosa
  9. Palliative and End-of-Life Care — Ezekiel J. Emanuel / Linda L. Emanuel
  10. Complementary and Alternative Medicine — Stephen E. Straus
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PART TWO — CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES

Section 1: Pain
  1. Pain: Pathophysiology and Management — Howard L. Fields/Joseph B. Martin
  2. Chest Discomfort and Palpitations — Thomas H. Lee
  3. Abdominal Pain — William Silen
  4. Headache — Neil H. Raskin
  5. Back and Neck Pain — John W. Engstrom
Section 2: Alterations in Body Temperature
  1. Fever and Hyperthermia — Charles A. Dinarello/Jeffrey A. Gelfand
  2. Fever and Rash — Elaine T. Kaye/Kenneth M. Kaye
  3. Fever of Unknown Origin — Jeffrey A. Gelfand/Michael V. Callahan
  4. Hypothermia and Frostbite — Daniel F. Danzl
Section 3: Nervous System Dysfunction
  1. Syncope, Faintness, Dizziness, and Vertigo — Robert B. Daroff/Mark D. Carlson
  2. Weakness, Disorders of Movement, and Imbalance — Richard K. Olney
  3. Numbness, Tingling, and Sensory Loss — Arthur K. Asbury
  4. Aphasia, Memory Loss, and Other Focal Cerebral Disorders — M-Marsel Mesulam
  5. Sleep Disorders — Charles A. Czeisler/John W. Winkelman/Gary S. Richardson
Section 4: Disorders of Eyes, Ears, Nose, and Throat
  1. Disorders of the Eye — Jonathan C. Horton
  2. Disorders of Smell, Taste, and Hearing — Anil K. Lalwani/James B. Snow, Jr.
  3. Infections of the Upper Respiratory Tract — Michael A. Rubin/Ralph Gonzales/Merle A. Sande
  4. Oral Manifestations of Disease — Samuel C. Durso
Section 5: Alterations in Circulatory and Respiratory Functions
  1. Dyspnea and Pulmonary Edema — Roland H. Ingram, Jr./Eugene Braunwald
  2. Cough and Hemoptysis — Steven E. Weinberger
  3. Hypoxia and Cyanosis — Eugene Braunwald
  4. Edema — Eugene Braunwald
Section 6: Alterations in Gastrointestinal Function
  1. Dysphagia — Raj K. Goyal
  2. Nausea, Vomiting, and Indigestion — William L. Hasler
  3. Diarrhea and Constipation — David A. Ahlquist/Michael Camilleri
  4. Weight Loss — Carol M. Reife
  5. Gastrointestinal Bleeding — Loren Laine
  6. Jaundice — Daniel S. Pratt/Marshall M. Kaplan
  7. Abdominal Swelling and Ascites — Robert M. Glickman
Section 7: Alterations in Renal and Urinary Tract Function
  1. Azotemia and Urinary Abnormalities — Bradley M. Denker/Barry M. Brenner
  2. Fluid and Electrolyte Disturbances — Gary G. Singer/Barry M. Brenner
  3. Acidosis and Alkalosis — Thomas D. DuBose, Jr.
Section 8: Alterations in Sexual Function and Reproduction
  1. Sexual Dysfunction — Kevin T. McVary
  2. Hirsutism and Virilization — David A. Ehrmann
  3. Infertility and Fertility Control — Janet E. Hall
Section 9: Alterations in the Skin
  1. Approach to the Patient with a Skin Disorder — Thomas J. Lawley/Kim B. Yancey
  2. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders — Calvin O. McCall/Thomas J. Lawley
  3. Skin Manifestations of Internal Disease — Jean L. Bolognia/Irwin M. Braverman
  4. Immunologically Mediated Skin Diseases — Kim B. Yancey/Thomas J. Lawley
  5. Cutaneous Drug Reactions — Olivier M. Chosidow/Robert S. Stern/ Bruce U. Wintroub
  6. Photosensitivity and Other Reactions to Light — David R. Bickers
Section 10: Hematologic Alterations
  1. Anemia and Polycythemia — John W. Adamson/Dan L. Longo
  2. Bleeding and Thrombosis — Robert I. Handin
  3. Enlargement of Lymph Nodes and Spleen — Patrick H. Henry/Dan L. Longo
  4. Disorders of Granulocytes and Monocytes — Steven M. Holland/John I. Gallin
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PART THREE — GENETICS AND DISEASE

  1. Principles of Human Genetics — J. Larry Jameson/Peter Kopp
  2. Chromosome Disorders — Terry Hassold/Stuart Schwartz
  3. The Practice of Genetics in Clinical Medicine — Susan Miesfeldt/J. Larry Jameson
  4. Stem Cell and Gene Transfer in Clinical Medicine — David Bodine/J. Larry Jameson/Ron McKay
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PART FOUR — NUTRITION

  1. Nutritional Requirements and Dietary Assessment — Johanna Dwyer
  2. Vitamin and Trace Mineral Deficiency and Excess — Robert M. Russell
  3. Malnutrition and Nutritional Assessment — Charles H. Halsted
  4. Enteral and Parenteral Nutrition Therapy — Lyn Howard
  5. Obesity — Jeffrey S. Flier/Eleftheria Maratos-Flier
  6. Eating Disorders — B. Timothy Walsh
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PART FIVE — ONCOLOGY AND HEMATOLOGY

Section 1: Neoplastic Disorders
  1. Approach to the Patient with Cancer — Dan L. Longo
  2. Prevention and Early Detection of Cancer — Otis W. Brawley/Barnett S. Kramer
  3. Cancer Genetics — Patrice J. Morin/Jeffrey M. Trent/Francis S. Collins/Bert Vogelstein
  4. Cancer Biology and Angiogenesis — Robert G. Fenton/Dan L. Longo
  5. Principles of Cancer Treatment: Surgery, Chemotherapy, and Biologic Therapy — Edward A. Sausville/Dan L. Longo
  6. Principles of Radiation Therapy — Stephen M. Hahn/Eli Glatstein
  7. Infections in Patients with Cancer — Robert Finberg
  8. Cancer of the Skin — Katarina G. Chiller/Carl Washington/Arthur J. Sober/Howard K. Koh
  9. Head and Neck Cancer — Everett E. Vokes
  10. Neoplasms of the Lung — John D. Minna
  11. Breast Cancer — Marc E. Lippman
  12. Gastrointestinal Tract Cancer — Robert J. Mayer
  13. Tumors of the Liver and Biliary Tract — Jules L. Dienstag/Kurt J. Isselbacher
  14. Pancreatic Cancer — Robert J. Mayer
  15. Bladder and Renal Cell Carcinomas — Howard I. Scher/Robert J. Motzer
  16. Hyperplastic and Malignant Diseases of the Prostate — Howard I. Scher
  17. Testicular Cancer — Robert J. Motzer/George J. Bosl
  18. Gynecologic Malignancies — Robert C. Young
  19. Soft Tissue and Bone Sarcomas and Bone Metastases — Shreyaskumar R. Patel/Robert S. Benjamin
  20. Metastatic Cancer of Unknown Primary Site — Richard M. Stone
  21. Paraneoplastic Syndromes: Endocrinologic/Hematologic — J. Larry Jameson/Bruce E. Johnson
  22. Paraneoplastic Neurologic Syndromes — Josep Dalmau/Myrna R. Rosenfeld
  23. Oncologic Emergencies — Rasim Gucalp/Janice Dutcher
  24. Late Consequences of Cancer and Its Treatment — Michael C. Perry/Dan L. Longo
Section 2: Hematopoietic Disorders
  1. Iron Deficiency and Other Hypoproliferative — John W. Adamson
  2. Anemias Hemoglobinopathies — Edward J. Benz
  3. Megaloblastic Anemias — Bernard M. Babior/H. Franklin Bunn
  4. Hemolytic Anemias and Acute Blood Loss — H. Franklin Bunn/Wendell Rosse
  5. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes — Neal S. Young
  6. Polycythemia Vera and Other Myeloproliferative Diseases — Jerry L. Spivak
  7. Acute and Chronic Myeloid Leukemia — Meir Wetzler/John C. Byrd/Clara D. Bloomfield
  8. Malignancies of Lymphoid Cells — James O. Armitage/Dan L. Longo
  9. Plasma Cell Disorders — Dan L. Longo/Kenneth C. Anderson
  10. Transfusion Biology and Therapy — Jeffery S. Dzieczkowski/Kenneth C. Anderson
  11. Hematopoietic Cell Transplantation — Frederick R. Appelbaum
Section 3: Disorders of Hemostasis
  1. Disorders of the Platelet and Vessel Wall — Robert I. Handin
  2. Disorders of Coagulation and Thrombosis — Robert I. Handin
  3. Antiplatelet, Anticoagulant, and Fibrinolytic Therapy — Steven R. Deitcher
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PART SIX — INFECTIOUS DISEASES

Section 1: Basic Considerations in Infectious Diseases
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  1. Introduction to Infectious Diseases: Host-Pathogen Interactions — Lawrence C. Madoff/Dennis L. Kasper
  2. Molecular Mechanisms of Microbial Pathogenesis — Gerald B. Pier
  3. Approach to the Acutely Ill Infected Febrile Patient — Tamar F. Barlam/Dennis L. Kasper
  4. Immunization Principles and Vaccine Use — Gerald T. Keusch/Kenneth J. Bart/Mark Miller
  5. Health Advice for International Travel — J.S. Keystone/P.E. Kozarsky
Section 2: Clinical Syndromes: Community-Acquired Infections
  1. Infective Endocarditis — Adolf W. Karchmer
  2. Infections of the Skin, Muscle, and Soft Tissues — Dennis L. Stevens
  3. Osteomyelitis — Jeffrey Parsonnet/James H. Maguire
  4. Intraabdominal Infections and Abscesses — Dennis L. Kasper/Dori F. Zaleznik
  5. Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning — Joan R. Butterton/Stephen B. Calderwood
  6. Clostridium difficile - Associated Disease, Including Pseudomembranous Colitis — Dale N. Gerding/Stuart Johnson
  7. Sexually Transmitted Diseases: Overview and Clinical Approach — King K. Holmes
Section 3: Clinical Syndromes: Nosocomial Infections
  1. Hospital-Acquired Infections — Robert A. Weinstein
  2. Infections in Transplant Recipients — Robert Finberg/Joyce Fingeroth
Section 4: Approach to Therapy for Bacterial Diseases
  1. Treatment and Prophylaxis of Bacterial Infections — Gordon L. Archer/Ronald E. Polk
Section 5: Diseases Caused by Gram-Positive Bacteria
  1. Pneumococcal Infections — Daniel M. Musher
  2. Staphylococcal Infections — Franklin D. Lowy
  3. Streptococcal and Enterococcal Infections — Michael R. Wessels
  4. Diphtheria and Other Corynebacterial Infections — Randall K. Holmes
  5. Infections Caused by Listeria monocytogenes — Anne Schuchat/Claire V. Broome
  6. Tetanus — Elias Abrutyn
  7. Botulism — Elias Abrutyn
  8. Gas Gangrene and Other Clostridial Infections — Dennis L. Kasper/Lawrence C. Madoff
Section 6: Diseases Caused by Gram-Negative Bacteria
  1. Meningococcal Infections — David Stephens/Robert S. Munford/Lee M. Wetzler
  2. Gonococcal Infections — Sanjay Ram/Peter A. Rice
  3. Moraxella catarrhalis and Other Moraxella Species — Daniel M. Musher
  4. Haemophilus Infections — Timothy F. Murphy
  5. Infections due to the HACEK Group and Miscellaneous Gram-Negative Bacteria — Dennis L. Kasper/Tamar F. Barlam
  6. Legionella Infection — Feng-Yee Chang/Victor L. Yu
  7. Pertussis and Other Bordetella Infections — Scott A. Halperin
  8. Diseases Caused by Gram-Negative Enteric Bacilli — Thomas A. Russo
  9. Helicobacter pylori Infections — John C. Atherton/Martin J. Blaser
  10. Infections Due to Pseudomonas Species and Related Organisms — Christopher A. Ohl/Matthew Pollack
  11. Salmonellosis — Cammie F. Lesser/Samuel I. Miller
  12. Shigellosis — Gerald T. Keusch/Dennis J. Kopecko
  13. Infections Due to Campylobacter and Related Species — Martin J. Blaser
  14. Cholera and Other Vibrioses — Matthew K. Waldor/Gerald T. Keusch
  15. Brucellosis — Michael J. Corbel/Nicholas J. Beeching
  16. Tularemia — Richard F. Jacobs
  17. Plague and Other Yersinia Infections — David T. Dennis/Grant L. Campbell
  18. Bartonella Infections, Including Cat-Scratch Disease — Lucy Stuart Tompkins
  19. Donovanosis — Gavin Hart
Section 7: Miscellaneous Bacterial Infections
  1. Nocardiosis — Gregory A. Filice
  2. Actinomycosis — Thomas A. Russo
  3. Infections due to Mixed Anaerobic Organisms — Dennis L. Kasper
Section 8: Mycobacterial Diseases
  1. Antimycobacterial Agents — Richard J. Wallace, Jr./Donald E. Griffin
  2. Tuberculosis — Mario C. Raviglione/Richard J. O'Brien
  3. Leprosy (Hansen's Disease) — Robert H. Gelber
  4. Nontuberculous Mycobacteria — C. Fordham von Reyn
Section 9: Spirochetal Diseases
  1. Syphilis — Sheila A. Lukehart
  2. Endemic Treponematoses — Sheila A. Lukehart
  3. Leptospirosis — Peter Speelman
  4. Relapsing Fever — David T. Dennis/Edward B. Hayes
  5. Lyme Borreliosis — Allen C. Steere
Section 10: Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia
  1. Rickettsial Diseases — David Walker/Didier Raoult/J. Stephen Dumler/Thomas Marrie
  2. Infections Due to Mycoplasmas — William M. McCormack
  3. Chlamydial Infections — Walter E. Stamm
Section 11: Viral Diseases: General Considerations
  1. Medical Virology — Fred Wang/Elliott Kieff
  2. Antiviral Chemotherapy, Excluding Antiretroviral Drugs — Lindsey R. Baden/Raphael Dolin
Section 12: Infections Due to DNA Viruses
  1. Herpes Simplex Viruses — Lawrence Corey
  2. Varicella-Zoster Virus Infections — Richard J. Whitley
  3. Epstein-Barr Virus Infections, Including Infectious Mononucleosis — Jeffrey I. Cohen
  4. Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 — Martin S. Hirsch
  5. Molluscum contagiosum and Other Poxviruses, Excluding Smallpox Virus — Fred Wang
  6. Parvovirus — Neil R. Blacklow
  7. Human Papillomavirus Infections — Richard C. Reichman
Section 13: Infections Due to DNA and RNA Respiratory Viruses
  1. Common Viral Respiratory Infections & Severe Acute Respiratory Syndrome — Raphael Dolin
  2. Influenza — Raphael Dolin
Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
  1. The Human Retroviruses — Dan L. Longo/Anthony S. Fauci
  2. Human Immunodeficiency Disease: AIDS and Related Disorders — Anthony S. Fauci/H. Clifford Lane
Section 15: Infections Due to RNA Viruses
  1. Viral Gastroenteritis — Umesh D. Parashar/Roger I. Glass
  2. Enteroviruses and Reoviruses — Jeffrey I. Cohen
  3. Measles (Rubeola) — Anne Gershon
  4. Rubella (German Measles) — Anne Gershon
  5. Mumps — Anne Gershon
  6. Rabies Virus and Other Rhabdoviruses — Cathleen A. Hanlon/Lawrence Corey
  7. Infections Caused by Arthropod- and Rodent-Borne Viruses — Clarence J. Peters
  8. Ebola and Marburg Viruses — Clarence J. Peters
Section 16: Fungal and Algal Infections
  1. Diagnosis and Treatment of Fungal Infection — John E. Bennett
  2. Histoplasmosis — John E. Bennett
  3. Coccidioidomycosis — John E. Bennett
  4. Blastomycosis — John E. Bennett
  5. Cryptococcosis — John E. Bennett
  6. Candidiasis — John E. Bennett
  7. Aspergillosis — John E. Bennett
  8. Mucormycosis — John E. Bennett
  9. Miscellaneous Mycoses and Algal Infections — John E. Bennett
  10. Pneumocystis Infection — Peter D. Walzer
Section 17: Protozoal and Helminthic Infections: General Considerations
  1. Laboratory Diagnosis of Parasitic Infections — Charles E. Davis
  2. Agents Used to Treat Infections Due to Parasites and Pneumocystis — Thomas A. Moore
Section 18: Protozoal Infections
  1. Amebiasis and Infection with Free-Living Amebas — Sharon L. Reed
  2. Malaria and Babesiosis: Diseases Caused by Red Blood Cell Parasites — Nicholas J. White/Joel G. Breman
  3. Leishmaniasis — Barbara L. Herwaldt
  4. Trypanosomiasis — Louis V. Kirchhoff
  5. Toxoplasma Infection — Lloyd H. Kasper
  6. Protozoal Intestinal Infections and Trichomoniasis — Peter F. Weller
Section 19: Helminthic Infections
  1. Trichinella and Other Tissue Nematodes — Peter F. Weller
  2. Intestinal Nematodes — Peter F. Weller/Thomas B. Nutman
  3. Filarial and Related Infections — Thomas B. Nutman/Peter F. Weller
  4. Schistosomiasis and Other Trematode Infections — Adel A.F. Mahmoud
  5. Cestodes — A. Clinton White, Jr./Peter F. Weller
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PART SEVEN — BIOTERRORISM AND CLINICAL MEDICINE

  1. Microbial Terrorism — H. Clifford Lane/Anthony S. Fauci
  2. Chemical Bioterrorism — Charles G. Hurst/Jonathan Newmark/James A. Romano
  3. Radiation Bioterrorism — Zelig A. Tochner/Ofer Lehavi/Eli Glatstein
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PART EIGHT — DISORDERS OF THE CARDIOVASCULAR SYSTEM

Section 1: Diagnosis of Cardiovascular Disorders
  1. Approach to the Patient with Cardiovascular Disease — Eugene Braunwald
  2. Physical Examination of the Cardiovascular System — Robert A. O'Rourke/Eugene Braunwald
  3. Electrocardiography — Ary L. Goldberger
  4. Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging — Rick A. Nishimura/Raymond J. Gibbons/James F. Glockner/A. Jamil Tajik
  5. Diagnostic Cardiac Catheterization and Angiography — Donald S. Baim/William Grossman
Section 2: Disorders of Rhythm
  1. The Bradyarrhythmias: Disorders of Sinus Node Function and AV Conduction Disturbances AV Conduction Disturbances — Mark E. Josephson/Peter Zimetbaum
  2. The Tachyarrhythmias — Mark E. Josephson/Peter Zimetbaum
Section 3: Disorders of the Heart
  1. Normal and Abnormal Myocardial Function — Eugene Braunwald
  2. Heart Failure and Cor Pulmonale — Eugene Braunwald
  3. Cardiac Transplantation and Prolonged Assisted Circulation — Sharon A. Hunt
  4. Congenital Heart Disease in the Adult — John S. Child/William F. Friedman
  5. Valvular Heart Disease — Eugene Braunwald
  6. Pulmonary Hypertension — Stuart Rich
  7. Cardiomyopathy and Myocarditis — Joshua Wynne/Eugene Braunwald
  8. Pericardial Disease — Eugene Braunwald
  9. Cardiac Tumors, Cardiac Manifestations of Systemic Diseases and Traumatic Cardiac Injury — Wilson S. Colucci/Daniel T. Price
Section 4: Vascular Disease
  1. The Pathogenesis of Atherosclerosis — Peter Libby
  2. Prevention and Treatment of Atherosclerosis — Peter Libby
  3. Ischemic Heart Disease — Andrew P. Selwyn/Eugene Braunwald
  4. Unstable Angina and Non-ST-Elevation Myocardial Infarction — Christopher P. Cannon/Eugene Braunwald
  5. ST-Segment Elevation Myocardial Infarction — Elliott M. Antman/Eugene Braunwald
  6. Percutaneous Coronary Revascularization — Donald S. Baim
  7. Hypertensive Vascular Disease — Naomi D.L. Fisher/Gordon H. Williams
  8. Diseases of the Aorta — Victor J. Dzau/Mark A. Creager
  9. Vascular Diseases of the Extremities — Mark A. Creager/Victor J. Dzau
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PART NINE — DISORDERS OF THE RESPIRATORY SYSTEM

Section 1: Diagnosis of Respiratory Disorders
  1. Approach to the Patient with Disease of the Respiratory System — Jeffrey M. Drazen/ Steven E. Weinberger
  2. Disturbances of Respiratory Function — Steven E. Weinberger/ Jeffrey M. Drazen
  3. Diagnostic Procedures in Respiratory Disease — Steven E. Weinberger/ Jeffrey M. Drazen
Section 2: Diseases of the Respiratory System
  1. Asthma — E.R. McFadden, Jr.
  2. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia — Joel N. Kline/Gary W. Hunninghake
  3. Environmental Lung Diseases — Frank E. Speizer
  4. Pneumonia — Thomas J. Marrie/G. Douglas Campbell/David H. Walker/Donald E. Low
  5. Bronchiectasis — Steven E Weinberger
  6. Cystic Fibrosis — Richard C. Boucher
  7. Chronic Obstructive Pulmonary Disease — John J. Reilly/Edwin K. Silverman/Steven D. Shapiro
  8. Interstitial Lung Diseases — Talmadge E. King, Jr.
  9. Pulmonary Thromboembolism — Samuel Z. Goldhaber
  10. Disorders of the Pleura, Mediastinum, Diaphragm, and Chest Wall — Richard W. Light
  11. Disorders of Ventilation — Eliot A. Phillipson
  12. Sleep Apnea — Eliot A. Phillipson
  13. Lung Transplantation — Elbert P. Trulock/ G. Alexander Patterson/Joel D. Cooper
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PART TEN — CRITICAL CARE MEDICINE

Section 1: Respiratory Critical Care
  1. Principles of Critical Care Medicine — John P. Kress/Jesse B. Hall
  2. Respiratory Failure — Craig Lilly/Edward P. Ingenito/Steven D. Shapiro
  3. Acute Respiratory Distress Syndrome — Bruce D. Levy/Steven D. Shapiro
  4. Mechanical Ventilatory Support — Edward P. Ingenito/Jeffrey M. Drazen
Section 2: Shock and Cardiac Arrest
  1. Approach to the Patient with Shock — Ronald V. Maier
  2. Severe Sepsis and Septic Shock — Robert S. Munford
  3. Cardiogenic Shock and Pulmonary Edema — Judith S. Hochman/David Ingbar
  4. Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death — Robert J. Myerburg/Agustin Castellanos
Section 3: Neurologic Critical Care
  1. Acute Confusional States and Coma — Allan H. Ropper
  2. Critical Care Neurology — J. Claude Hemphill
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PART ELEVEN — DISORDERS OF THE KIDNEY AND URINARY TRACT

  1. Adaptation to Renal Injury — Robert M. Brenner/ Barry M. Brenner
  2. Acute Renal Failure — Hugh R. Brady/ Barry M. Brenner
  3. Chronic Renal Failure — Karl Skorecki/Jacob Green/Barry M. Brenner
  4. Dialysis in the Treatment of Renal Failure — Ajay K. Singh/Barry M. Brenner
  5. Transplantation in the Treatment of Renal Failure — Charles B. Carpenter/Edgar L. Milford/Mohamed H. Sayegh
  6. Glomerular Diseases — Hugh R. Brady/Yvonne M. O'Meara/Barry M. Brenner
  7. Tubular Disorders — John R. Asplin/Fredric L. Coe
  8. Tubulointerstitial Diseases of the Kidney — Alan S. L. Yu/Barry M. Brenner
  9. Vascular Injury to the Kidney — Kamal F. Badr/Barry M. Brenner
  10. Nephrolithiasis — John R. Asplin/Fredric L. Coe/Murray J. Favus
  11. Urinary Tract Infections and Pyelonephritis — Walter E. Stamm
  12. Urinary Tract Obstruction — Julian L. Seifter/Barry M. Brenner
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PART TWELVE — DISORDERS OF THE GASTROINTESTINAL SYSTEM

Section 1: Disorders of the Alimentary Tract
  1. Approach to the Patient with Gastrointestinal Disease — William L. Hasler/Chung Owyang
  2. Gastrointestinal Endoscopy — Mark Topazian
  3. Diseases of the Esophagus — Raj K. Goyal
  4. Peptic Ulcer Disease and Related Disorders — John Del Valle
  5. Disorders of Absorption — Henry J. Binder
  6. Inflammatory Bowel Disease — Sonia Friedman/Richard S. Blumberg
  7. Irritable Bowel Syndrome — Chung Owyang
  8. Familial Mediterranean Fever and Other Hereditary Recurrent Fevers — Daniel L. Kastner
  9. Common Diseases of the Colon and Anorectum and Mesenteric Vascular Insufficiency — L. Gearhart/Gregory Bulkley
  10. Acute Intestinal Obstruction — William Silen
  11. Acute Appendicitis and Peritonitis — William Silen
Section 2: Liver and Biliary Tract Disease
  1. Approach to the Patient with Liver Disease — Marc Ghany/Jay H. Hoofnagle
  2. Evaluation of Liver Function — Daniel S. Pratt/Marshall M. Kaplan
  3. The Hyperbilirubinemias — Allan W. Wolkoff
  4. Acute Viral Hepatitis — Jules L. Dienstag/Kurt J. Isselbacher
  5. Toxic and Drug-Induced Hepatitis — Jules L. Dienstag/Kurt J. Isselbacher
  6. Chronic Hepatitis — Jules L. Dienstag/Kurt J. Isselbacher
  7. Alcoholic Liver Disease — Mark E. Milliard/Michael F. Sorrell
  8. Cirrhosis and Its Complications — Raymond T. Chung/Daniel K. Podolsky
  9. Infiltrative, Genetic, and Metabolic Diseases Affecting the Liver — Daniel K Podolsky
  10. Liver Transplantation — Jules L. Dienstag
  11. Diseases of the Gallbladder and Bile Ducts — Norton J. Greenberger/Gustav Paumgartner
Section 3: Disorders of the Pancreas
  1. Approach to the Patient with Pancreatic Disease — Phillip P. Toskes/Norton J. Greenberger
  2. Acute and Chronic Pancreatitis — Norton J. Greenberger/Phillip P. Toskes
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PART THIRTEEN — DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS

Section 1: The Immune System in Health and Disease
  1. Introduction to the Immune System — Barton F. Haynes/Anthony S. Fauci
  2. The Major Histocompatibility Gene Complex — Gerald T. Nepom/Joel D. Taurog
  3. Primary Immune Deficiency Diseases — Max D. Cooper/Harry W. Schroeder, Jr.
Section 2: Disorders of Immune-Mediated Injury
  1. Allergies, Anaphylaxis, and Systemic Mastocytosis — K. Frank Austen
  2. Autoimmunity and Autoimmune Diseases — Peter E. Lipsky/Betty Diamond
  3. Systemic Lupus Erythematosus — Bevra Hannahs Hahn
  4. Rheumatoid Arthritis — Peter E. Lipsky
  5. Rheumatic Fever — Edward L. Kaplan
  6. Systemic Sclerosis (Scleroderma) and Related Disorders — Bruce C. Gilliland
  7. Sjögren's Syndrome — Haralampos M. Moutsopoulos
  8. The Spondyloarthritidies — Joel D. Taurog
  9. The Vasculitis Syndromes — Michael C. Sneller/Carol A. Langford/Anthony S. Fauci
  10. Behçet's Syndrome — Haralampos M. Moutsopoulos
  11. Relapsing Polychondritis — Bruce C. Gilliland
  12. Sarcoidosis — Ronald G. Crystal
  13. Amyloidosis — Jean D. Sipe/Alan S. Cohen
Section 3: Disorders of the Joints and Adjacent Tissues
  1. Approach to Articular and Musculoskeletal Disorders — John J. Cush/Peter E. Lipsky
  2. Osteoarthritis — Kenneth D. Brandt
  3. Gout and Other Crystal Arthropathies — Antonio J. Reginato
  4. Infectious Arthritis — Lawrence C. Madoff/Scott J. Thaler/James H. Maguire
  5. Fibromyalgia, Arthritis Associated with Systemic Diseases, and Other Arthritides — Bruce C. Gilliland
  6. Periarticular Disorders of the Extremities — Bruce C. Gilliland
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PART FOURTEEN — ENDOCRINOLOGY AND METABOLISM

Section 1: Endocrinology
  1. Principles of Endocrinology — J. Larry Jameson
  2. Disorders of the Anterior Pituitary and Hypothalamus — Shlomo Melmed/J. Larry Jameson
  3. Disorders of the Neurohypophysis — Gary L. Robertson
  4. Diseases of the Thyroid Gland — J. Larry Jameson/Anthony P. Weetman
  5. Disorders of the Adrenal Cortex — Gordon H. Williams/Robert G. Dluhy
  6. PheochromocytomavLewis Landsberg/James B. Young
  7. Diabetes Mellitus — Alvin C. Powers
  8. Hypoglycemia — Philip E. Cryer
  9. Disorders of the Testes and Male Reproductive System — Shalendar Bhasin/J. Larry Jameson
  10. Disorders of the Ovary and Female Reproductive Tract — Bruce R. Carr/Karen D. Bradshaw
  11. The Menopause Transition and Postmenopausal Hormone Therapy — JoAnn E. Manson/Shari S. Bassuk
  12. Disorders of Sexual Differentiation — John C. Achermann/J. Larry Jameson
  13. Endocrine Tumors of the Gastrointestinal Tract and Pancreas — Robert T. Jensen
  14. Disorders Affecting Multiple Endocrine Systems — Steven I. Sherman/Robert F. Gagel
Section 2: Disorders of Bone and Mineral Metabolism
  1. Bone and Mineral Metabolism in Health and Disease — F. Richard Bringhurst/Marie B. Demay/Stephen M. Krane/Henry M. Kronenberg
  2. Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemic Disorders — John T. Potts, Jr.
  3. Osteoporosis — Robert Lindsay/Felicia Cosman
  4. Paget Disease and Other Dysplasias of Bone — Murray J. Favus/Tamara J. Vokes
Section 3: Disorders of Intermediary Metabolism
  1. Disorders of Lipoprotein Metabolism — Daniel J. Rader/Helen H. Hobbs
  2. Hemochromatosis — Lawrie W. Powell
  3. The Porphyrias — Robert J. Desnick
  4. Disorders of Purine and Pyrimidine Metabolism — Robert L. Wortmann
  5. Wilson Disease — George J. Brewer
  6. Lysosomal Storage Diseases — Robert J. Hopkin/Gregory A. Grabowski
  7. Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism — Yuan-Tsong Chen
  8. Inherited Disorders of Connective Tissue — Darwin J. Prockop/Leena Ala-Kokko
  9. Inherited Disorders of Amino Acid Metabolism Presenting in Adults — Nicola Longo
  10. Inherited Defects of Membrane Transport — Nicola Longo
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PART FIFTEEN — NEUROLOGIC DISORDERS

Section 1: Diagnosis of Neurologic Disorders
  1. Neurobiology of Disease — Stephen L. Hauser/M. Flint Beal
  2. Approach to the Patient with Neurologic Disease — Joseph B. Martin/Daniel H. Lowenstein/Stephen L. Hauser
  3. Neuroimaging in Neurologic Disorders — William P. Dillon
Section 2: Diseases of the Central Nervous System
  1. Seizures and Epilepsy — Daniel H. Lowenstein
  2. Cerebrovascular Diseases — Wade S. Smith/S. Claiborne Johnston/J. Donald Easton
  3. Alzeimer's Disease and Other Dementias — Thomas D. Bird/Bruce L. Miller
  4. Parkinson's Disease and Other Movement Disorders — Mahlon R. DeLong/Jorge L. Juncos
  5. Ataxic Disorders — Roger N. Rosenberg
  6. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases — Robert H. Brown, Jr.
  7. Disorders of the Autonomic Nervous System — Phillip A. Low/John W. Engstrom
  8. Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders — M. Flint Beal/Stephen L. Hauser
  9. Diseases of the Spinal Cord — Stephen L. Hauser/Allan H. Ropper
  10. Concussion and Other Head Injuries — Allan H. Ropper
  11. Primary and Metastatic Tumors of the Nervous System — Stephen M. Sagar/Mark A. Israel
  12. Multiple Sclerosis and Other Demyelinating Diseases — Stephen L. Hauser/Douglas S. Goode
  13. Meningitis, Encephalitis, Brain Abscess, and Empyema — Karen L. Roos/Kenneth L. Tyler
  14. Chronic and Recurrent MeningitisWalter J. Koroshetz/Morton N. Swartz
  15. Prion Diseases — Stanley B. Prusiner/Bruce Miller
Section 3: Disorders of Nerves and Muscles
  1. Approach to the Patient with Peripheral Neuropathy — Arthur K. Asbury
  2. Charcot-Marie-Tooth Disease and Other Inherited Neuropathies — Philip F. Chance/Thomas D. Bird
  3. Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies — Stephen L. Hauser/Arthur K. Asbury
  4. Myasthenia Gravis and Other Diseases of the Neuromuscular Junction — Daniel B. Drachman
  5. Approach to the Patient with Muscle Disease — Jerry R. Mendell
  6. Muscular Dystrophies and Other Muscle Diseases — Robert H. Brown, Jr./Jerry R. Mendell
  7. Polymyositis, Dermatomyositis, and Inclusion Body Myositis — Marinos C. Dalakas
Section 4: Chronic Fatigue Syndrome
  1. Chronic Fatigue Syndrome — Stephen E. Straus
Section 5: Psychiatric Disorders
  1. Mental Disorders — Victor I. Reus
Section 6: Alcoholism and Drug Dependency
  1. Alcohol and Alcoholism — Marc A. Schuckit
  2. Opioid Drug Abuse and Dependence — Marc A. Schuckit/David S. Segal
  3. Cocaine and Other Commonly Abused Drugs — Jack H. Mendelson/Nancy K. Mello
  4. Nicotine Addiction — David M. Burns
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PART SIXTEEN — POISONING, DRUG OVERDOSE, AND ENVENOMATION

  1. Heavy Metal Poisoning — Howard Hu
  2. Poisoning and Drug Overdosage — Christopher H. Linden/Michael J. Burns
  3. Disorders Caused by Reptile Bites and Marine Animal Exposures — Paul S. Auerbach/Robert L. Norris
  4. Ectoparasite Infestations and Arthropod Bites and Stings — James H. Maguire/Richard J. Pollack/Andrew Spielman
  1. Appendices: Laboratory Values of Clinical Importance — Alexander Kratz/Patrick M. Sluss/James L. Januzzi, Jr./Kent B. Lewandrowski
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