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Microbiology, 5/e

Lansing M Prescott, Augustana College
Donald A Klein, Colorado State University
John P Harley, Eastern Kentucky University

Microbial Genomics

Multiple Choice Quiz

Choose the best answer


1	The study of the molecular organization of genomes, their information content and the gene products they encode
		A)	genetics
		B)	genomics
		C)	ergonomics


2	Which type of genomics studies the physical nature of genomes?
		A)	comparative genomics
		B)	structural genomics
		C)	functional genomics


3	Which type of genomics studies the transcripts and proteins expressed by a genome?
		A)	comparative genomics
		B)	structural genomics
		C)	functional genomics


4	Which type of genomics studies similarities and differences among the genomes of multiple organisms?
		A)	comparative genomics
		B)	structural genomics
		C)	functional genomics


5	Who first developed the DNA sequencing approach using dideoxynucleoside triphosphates in DNA synthesis?
		A)	Pauling
		B)	Watson
		C)	Sanger


6	How are the four different bases distinguished in automated sequencing systems?
		A)	each base has a different radioactive tag
		B)	each base has a distinctive fluorescent tag
		C)	each base has a unique antibody bound to it


7	Which bacterial genome was the first to be completely sequenced?
		A)	E. coli
		B)	Streptococcus pneumoniae
		C)	Haemophilus influenzae


8	The whole-genome shotgun sequencing approach depends primarily on
		A)	rapidly sequencing thousands of small randomly cloned fragments
		B)	methodical sequencing a few large cloned fragments of DNA
		C)	sequencing the bacterial chromosome while it is still intact


9	The goal of ________________ is to determine the location of specific genes within the genome.
		A)	cloning
		B)	annotation
		C)	proteomics


10	An open reading frame (ORF) is
		A)	the sequence of a complete genome
		B)	a plasmid vector used in genome sequencing
		C)	a possible gene predicted by DNA sequencing


11	The field that is concerned with the management and analysis of biological data using computers
		A)	statistics
		B)	genomics
		C)	bioinformatics


12	Which of these organisms has the smallest genome?
		A)	Haemophilus influenzae
		B)	Mycoplasma genitalium
		C)	Mycobacterium tuberculosis


13	The minimum set of genes required for life is approximately:
		A)	50-100 genes
		B)	250-350 genes
		C)	1000-1500 genes


14	Deinococcu radiodurans is able to survive massive exposure to radiation because
		A)	it produces a thick shell which acts as a shield from the radiation
		B)	it has unique DNA repair mechanisms
		C)	it has many copies of genes encoding DNA repair


15	The genomic sequence of the obligate intracellular parasite Rickettsia prowazekii supported the theory that:
		A)	all bacteria evolved from viruses
		B)	mitochondria have evolved from endosymbiotic bacteria
		C)	parasitic bacteria have very large genomes


16	The bacterium Treponema pallidum is difficult to culture because
		A)	it lacks the genes needed for TCA cycle and oxidative phosphorylation
		B)	it is unable to use carbohydrates as an energy source
		C)	it requires a great deal of water to reproduce


17	Which species of bacteria possesses 250 genes for lipid biosynthesis?
		A)	E. coli
		B)	Mycobacterium tuberculosis
		C)	Mycoplasma genitalium


18	In the time since E. coli and Salmonella diverged evolutionarily
		A)	There has been little change in either genome
		B)	E. coli has lost approximately 50% of its genome
		C)	E. coli has acquired may genes via horizontal transfer


19	Small solid supports onto which are spotted hundreds of thousands of tiny drops of DNA that can be used to screen gene expression.
		A)	DNA microarrays
		B)	cloning library
		C)	Southern blot


20	Proteomics is:
		A)	a branch of quantum physics
		B)	the study of algal genomes
		C)	the study of the entire collection of proteins expressed by an organism


21	The first dimension of separation for two-dimensional electrophoresis is based on ________
		A)	molecular mass
		B)	isoelectric point
		C)	folding


22	The first dimension of separation for two-dimensional electrophoresis is based on ________
		A)	molecular mass
		B)	isoelectric point
		C)	folding

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