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Hole's Essentials of Human Anatomy & Physiology, 8/e
David N. Shier, Washtenaw Community College
Jackie L. Butler, Grayson County College
Ricki Lewis, SUNY - Albany


Laboratory Exercises

Explore these links to websites that provide online virtual labs, tutorials, and dissections.

3D Virtual Colonoscopy

http://www.cs.sunysb.edu/~vislab/projects/colonoscopy/colonoscopy.html

This project employs advanced visualization techniques to achieve virtual imaging and exploration of the human colon. The data sets that have been successfully applied in our experiments include the Visible Human, a simulated plastic pipe, and patient data (provided by the University Hospital at Stony Brook).

Anatomy

http://calloso.med.mun.ca/~tscott/gross.htm

This is an interactive site that provides information along with images about different parts of the human body. (All links are accessible except "Integrated Study of Disease Cases," which requires a PIN)

Atom World: Tutorial

http://www.jlc.net/~aretee/atomworld/tutorial.html

By "quick" we mean that in 10 minutes of your time, you'll have a working knowledge of chemistry. Skeptical? The secret is we're not using math! And don't worry - we're not going to teach you TOO much chemistry, but we will give you enough to understand the most important things that are going on.

Biochemistry

http://www.biology.arizona.edu/biochemistry/tutorials/chemistry/main.html

Review activities and tutorials in basic chemistry, metabolism, enzymes, energy, & catalysis, large molecules, photosynthesis, pH & pKa, clinical correlates of pH, vitamins B12 and Folate, and regulation of carbohydrate metabolism.

Biointeractives-go to Click and Learn

http://www.biointeractive.org/

ANTIBIOTICS ATTACK!: How do they work? How do bacteria fight back? Animations and quizzes help you understand how antibiotics target wily bacteria--but why they don't always get their germ.

A PRIMER ON THE ELECTROCARDIOGRAM: What's an electrocardiogram (ECG)? Check out this introductory summary about the science and technology of monitoring the electrical activity of the heart. Shockwave Player required.

HEART SIZE IN MAMMALS: What is the relationship between heart rate and size? Does resting heart rate vary in a consistent way as size changes? Check out this interactive animation that illustrates this correlation.

THE KIDNEY SCOPE: Do you know what our kidneys do? You might be aware that kidneys somehow make urine. How do they do that? Take a quick tour and find out how the kidney does its job.

Biointeractives- go to Virtual Museum

http://www.biointeractive.org/

WHEN WORLDS COLLIDE: MICRO VERSUS MACRO

Although humans have long observed the devastating effects of infectious diseases, the microscope made it possible to see the pathogens. Today, the genomics revolution lets scientists "see" the microbial world in greater detail, leading to custom-designed drugs and therapies. Despite advances in science and medicine, infectious diseases will continue to threaten human health. Explore this exhibit to learn about the challenges posed by infectious diseases-and to "meet" scientists like Pasteur and Koch, whose insights have contributed to our understanding.

VITAL SIGNS: UNDERSTANDING CARDIOVASCULAR DISEASES

Early in this century, doctors had few tools to help them diagnose or treat diseases, and they had limited understanding of cardiovascular illness. Heart surgery was nearly inconceivable. Today, mortality due to heart disease is declining, open-heart surgery is commonplace, and people have the information they need to make changes in their lives that alleviate or even prevent cardiovascular illness.

HEARING AND SEEING: MODELS FOR THOUGHT

Science is largely driven by curiosity and the desire to understand our place in the world. Neuroscience, focused on understanding how nervous systems work, is no exception. Diverse tools and methods are used to explore topics such as sensory perception, the control of movement, and even thinking.

Biointeractives-Virtual Labs

http://www.biointeractive.org/

THE BACTERIAL ID LAB: Use cutting-edge DNA sequencing techniques and powerful database searches to identify an unknown bacterial species! In this lab, you will learn about polymerase chain reaction (PCR), automatic DNA sequencers, and the science of using a database of known DNA sequences to identify an organism.

THE CARDIOLOGY LAB: The focus of this lab is on heritable diseases of the heart. You are cast here as a virtual intern to accompany a doctor examining different patients. Each patient is examined using more than one diagnostic tool and at each stage, the doctor will invite you to examine the patient yourself and ask for your opinion.

THE NEUROPHYSIOLOGY LAB: In the neurophysiology virtual lab, we will explore the sensory system of the leech. Why the leech? The leech's nervous system is very simple and easily accessible. Thus, unlike the incredibly complicated human brain, the leech system can be understood more easily.

ELISA ASSAY: Components of the immune system called antibodies are found in the liquid portion of blood and help protect the body from harm. Antibodies also can be used also outside the body in a laboratory-based assay to help diagnose disease caused by malfunctions of the immune system or by infections. This virtual laboratory will demonstrate how such a test, termed an enzyme-linked immunosorbent assay (ELISA), is carried out and some of the key experimental problems that may be encountered.

Blood, Sweat, and Buffers: pH Regulation During Exercise

http://wunmr.wustl.edu/EduDev/LabTutorials/Buffer/Buffer.html

This tutorial reviews how exercise affects the body, written from a chemist's perspective.

Blood Types Tutorial

http://www.biology.arizona.edu/human_bio/problem_sets/blood_types/Intro.html

The Human Genetics Tutorial provides problem solving exercises concerning the inheritance of the ABO blood group alleles

The Cardiovascular System

http://projects.edte.utwente.nl/pi/Java/Simulaties/CardioP1/Cardio.htm

The computer simulation program CARDIO enables students to experiment with the basic principles of blood pressure regulation.

Catalase Lab

http://chem.lapeer.org/Bio2Docs/CatalaseLab.html

In this lab a catalase solution is used to determine the effect of temperature and pH on the action of this enzyme.

Cell Biology

http://www.biology.arizona.edu/cell_bio/cell_bio.html

These problem sets and tutorials review studying cells, mitosis, meiosis, the cell cycle, prokaryotes, eukaryotes, & viruses.

Chemicals and Human Health

http://www.biology.arizona.edu/chh/

These problem sets and tutorials review basic toxicology, lung toxicology, environmental tobacco smoke & lung development, kidneys & metals.

Developmental Biology

http://www.biology.arizona.edu/developmental_bio/developmental_bio.html

These problem sets and tutorials review developmental mechanisms.

The Digital Anatomy Lab

http://www.dal.qut.edu.au/DALhome.html

This site was designed to enhance learning in topics such as Medical Engineering, Life Science & Medical Physics through incorporation of the Visible Human Project images.

Drug Calculations for Nurses

http://www.geocities.com/HotSprings/8517/Quiz/quiz.htm

Quizzes for metric conversions, tablet dosage calculations, fluid dosage calculations, and IV drop rate calculations.

Frog Anatomy / Dissection

http://www.kent.wednet.edu/staff/rlynch/sci_class/chap15/frog_dissect.html

The Heart: An Online Exploration

http://sln.fi.edu/biosci/heart.html

Explore the heart. Discover the complexities of its development and structure. Follow the blood through the blood vessels. Wander through the weblike body systems. Learn how to have a healthy heart and how to monitor your heart's health. Look back at the history of heart science.

Histology Tutorial

http://www.medinfo.ufl.edu/year1/histo/

As you study Histology, this program may be useful for you to review before and after lab sessions where you look at the "real thing" with your microscope.

Human Biology

http://www.biology.arizona.edu/human_bio/human_bio.html

These problem sets and tutorials review DNA forensics, karyotyping, genetics, blood types, reproduction, and sexually transmitted diseases.

Immunology

http://www.biology.arizona.edu/immunology/immunology.html

These problem sets and tutorials review immunology, HIV, the ELISA assay, and Western blotting analysis.

Insight Online

http://www.innerbody.com/htm/body.html

Insight Online is designed to provide instant logical flow between all of its related images, animations, and descriptions. To make learning easier, the Insight program is divided into systems. They can be accessed at the main system menu or from the system listing page.

Interactive Atlases Digital Anatomist Project

http://www9.biostr.washington.edu/da.html

2-D and 3-D views of the brain from cadaver sections, MRI scans, and computer reconstructions.

The Interactive Frog Dissection

http://teach.virginia.edu/go/frog

This interactive frog dissection was designed as a valuable preparation tool for laboratory dissection.

Laboratory Exercises for Pathology

Laboratory of Molecular Cell Biology

http://web-mcb.agr.ehime-u.ac.jp/english/bunnshi/default.htm

Provides an on-line data source for standard cell biology laboratories or for inquiry-based education.

Mendelian Genetics

http://www.biology.arizona.edu/mendelian_genetics/mendelian_genetics.html

These problem sets and tutorials review monohybrid cross, dihybrid cross, and sex-linked inheritance.

MicroScape Virtual Laboratory

http://www.microscopy.com/MicroScape/MicroScape.html

In the MicroScape Virtual Laboratory you will find a collection of "Digital" images which begin at High Magnification and progress down in Magnification simulating an on-line "Virtual Microscope". Using the single frame advance option of the QT display software you can step through these images slowly increasing or decreasing the magnification over the range provided by the library sequence, much like you would by changing the magnification in a real microscope. Using the interactive controls you will be able to vary the magnified image view up and down.

Molecular Biology

http://www.biology.arizona.edu/molecular_bio/molecular_bio.html

These problem sets and tutorials review nucleic acids, genetics of prokaryotes, genetics of eukaryotes, and recombinant DNA.

Virtual Frog Dissection Kit

http://www-itg.lbl.gov/ITG.hm.pg.docs/dissect/info.html

This award-winning interactive program is part of the "Whole Frog" project. You can interactively dissect a (digitized) frog named Fluffy, make movies, and play the Virtual Frog Builder Game. The interactive Web pages are available in a number of languages.

Virtual Physiology Laboratory

http://www.life.sci.qut.edu.au/research/virt_lab.htm

This site describes a series of safe, simple exercises you can carry out at home, without the need for complicated apparatus. You may sometimes need the services of a willing helper but they don't have to be trained physiologists! The site will provide you with all the instructions, what you need to find at home, how to interpret the results and the significance of your findings. There is no need to go through the experiments in a particular order, they are all self-contained exercises.

    1. CARDIAC PHYSIOLOGY
    2. PERIPHERAL CIRCULATION
    3. NEURAL RECEPTOR PHYSIOLOGY
    4. RESPIRATION
    5. DIGESTION
    6. FLUID BALANCE
    7. TEMPERATURE REGULATION
The Whole Brain Atlas

http://www.med.harvard.edu/AANLIB/home.html

Presents the following topics: Normal Brain, Cerebrovascular Disease (stroke), Neoplastic Disease (brain tumor), Degenerative Disease, Inflammatory or Infectious Disease

The Whole Frog Project

http://george.lbl.gov/ITG.hm.pg.docs/Whole.Frog/Whole.Frog.html

The ITG "Whole Frog" project is intended to introduce the concepts of modern, computer based 3D visualization, and at the same time to demonstrate the power of whole body, 3D imaging of anatomy as a curriculum tool.