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Multiple Choice Quiz
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1

The term cancer means
A)cell division.
B)out of control.
C)crab.
D)lobster.
2

Cancer is often the result of activation of ____ to ____ and the inactivation of ____ genes.
A)oncogenes, tumor-suppressor genes, proto-oncogenes
B)proto-oncogenes, oncogenes, tumor-suppressor genes
C)oncogenes, proto-oncogenes, tumor-suppressor genes
D)proto-suppressor genes, suppressors, oncogenes
3

About 50% of all human cancers may involve an abnormal or missing
A)oncogene.
B)proto-oncogene.
C)p53 gene.
D)BRCA-1 gene.
4

Inherited retinoblastoma requires ____ mutation(s) or deletion(s).
A)one
B)two
C)three
D)four
5

In which of the human cells listed below is telomerase active?
A)blood
B)bone
C)muscle
D)sperm
6

Which of the following is not a characteristic of cancer cells?
A)loss of cell cycle control
B)transplantability
C)loss of contact inhibition
D)all are characteristic
7

The Philadelphia chromosome is associated with which type of cancer?
A)breast
B)thyroid
C)nerve
D)leukemia
8

BRCA-1 is associated with which cancer?
A)breast
B)thyroid
C)nerve
D)leukemia
9

If 85% of lung cancer cases occur in heavy smokers, can lung cancer still have a genetic origin?
A)yes
B)no
10

An increasing number of women in the rural south die from ____ cancer.
A)breast
B)colon
C)lung
D)mouth
11

Which of the following statements about telomerase is incorrect?
A)It is an enzyme that adds DNA to telomeres.
B)It serves as the template for telomeres lengthening.
C)It is not activated in cancer cells.
D)Its activity continually resets the cellular clock.
12

Familial cancer is caused by
A)a mutation in somatic cells only.
B)a mutation in germline cells only.
C)a germline mutation plus a somatic mutation in affected tissue.
D)two germline mutations.
13

A cancerous tumor eventually grows faster than surrounding tissues because a greater proportion of its cells are dividing. True or false?
A)true
B)false
14

Which type of cancer in humans is directly caused by a viral infection?
A)acute T cell leukemia
B)Wilms' tumor
C)Burkitt's lymphoma
D)Rous sarcoma
15

An oncogene transcribed and translated with another gene produces a
A)transcribed protein.
B)fusion protein.
C)fusion cell.
D)cancer protein.
16

The P53 protein normally promotes
A)DNA repair.
B)tumor formation.
C)cell division.
D)apoptosis.
17

The P53 gene is especially prone to
A)point mutation.
B)chromosomal rearrangement.
C)loss.
D)none of the above.
18

FAP colon cancer results from ____ mutation(s).
A)one
B)two
C)three
D)four or more
19

Which type of study compares the incidence of a type of cancer among very different groups of people?
A)population
B)case-control
C)prospective
D)empiric
20

Which type of study would compare cancer rates seen in a group of individuals who take herbal supplements versus those in a control group who do not use the supplement?
A)population
B)case-control
C)prospective
D)empiric
21

Which of the following cancers develops from loss of tumor suppression?
A)cute T cell leukemia
B)Wilms' tumor
C)Burkitt's lymphoma
D)Rous sarcoma
22

Why is genetic counseling for familial breast cancer difficult?
A)BRCA1 and BRCA2 are incompletely penetrant.
B)Breast cancer can occur in other ways.
C)Not all mutations are associated with disease.
D)all of the above
23

Which of the following is not a traditional cancer treatment?
A)blocking telomerase
B)inhibiting angiogenesis
C)stimulating specialization
D)none of the above
24

A mutation in which gene makes nearby DNA more susceptible to replication errors?
A)APC
B)BRCA1
C)P53
D)RB
25

Which of the following may contribute to causing cancer?
A)a mutation in a gene that slows the cell cycle
B)faulty DNA repair
C)loss of control over telomere length
D)all of the above





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