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Multiple Choice Quiz
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1

Germ-line therapy is
A)heritable.
B)not heritable.
C)sometimes heritable.
D)unrelated to heritability.
2

The first gene therapy used cells altered outside the recipient's body and is called ____ gene therapy.
A)in situ
B)in vivo
C)ex vivo
D)vaccine
3

Which of the following is not a vector used in gene therapy?
A)AAV
B)herpes
C)retrovirus
D)HIV
4

A transgenic mouse is an example of
A)germline gene therapy.
B)heritable gene therapy.
C)constitutional gene therapy.
D)somatic gene therapy.
5

Germline gene therapy could potentially correct a genetic defect in a(n)
A)affected individual only.
B)affected individual and his or her offspring only.
C)affected individual and all of his or her descendants.
D)parent of an affected child.
6

Which cell type would not be a direct target for gene therapy?
A)red blood
B)muscle
C)liver
D)endothelium
7

Fetal hematopoietic stem cells used in gene therapy can be obtained from
A)the embryo.
B)the fetus.
C)the placenta.
D)the yolk sac.
8

A mechanism of gene therapy involving the alteration of myoblasts could be used to treat
A)cystic fibrosis.
B)muscular dystrophy.
C)ataxia.
D)Tay-Sachs disease.
9

Which of the following is a preferred vector for transferring genes to nerve cells?
A)AAV
B)herpes
C)retrovirus
D)HIV
10

Enabling tumor cells to produce immune system biochemicals is an approach called
A)cancer surgery.
B)a cancer vaccine.
C)a cancer target.
D)none of the above.
11

____ deficiency was the first disorder researchers treated with gene therapy.
A)ADA
B)OTC
C)HH
D)DMD
12

Gene therapy targets
A)genotypes.
B)phenotypes.
C)either a or b depending on the application.
D)both genotypes and phenotypes.
13

Chimeraplasty attempts to
A)replace an abnormal gene.
B)repair an abnormal gene in place.
C)remove an abnormal gene.
D)replace one normal allele with a different normal allele.
14

Why are neurons difficult targets for gene therapy?
A)they are not easily accessible
B)they are small
C)they do not divide
D)they lack a nucleus
15

About one half of current gene therapy trials target
A)cystic fibrosis.
B)cancer.
C)ADA deficiency.
D)sickle cell disease.
16

Melanoma is amenable to ____ treatment.
A)chimeraplasty
B)protein based
C)suicide gene
D)vaccine
17

Which vector used in gene therapy infects nerve cells and can be used to treat brain tumors?
A)adeno-associated virus
B)adenovirus
C)herpes virus
D)retrovirus
18

Which vector used in gene therapy has proved useful in the treatment of sickle cell disease?
A)adeno-associated virus
B)adenovirus
C)herpes virus
D)retrovirus
19

Hydroxyurea has been useful in the treatment of sickle cell disease because it
A)destroys sickled blood cells.
B)raises fetal hemoglobin levels.
C)raises stem cell numbers.
D)transfers new genes to red blood cells.
20

Jesse Gelsinger died during a gene therapy experiment aimed at treating his ____ deficiency.
A)ADA
B)OTC
C)Canavan
D)DMD
21

Genetic counselors encourage informed decision making but if necessary, they take steps to influence the reproductive decisions of couples who carry recessive disease alleles. True or false?
A)true
B)false
22

What type of genetic screening tests would focus on the breast and ovarian cancer genes BRCA1 and BRCA2?
A)prenatal
B)carrier screening
C)inherited predisposition
D)newborn
23

A man and woman, each with a family history of sickle cell disease and no children would benefit most by
A)prenatal screening.
B)carrier screening.
C)inherited predisposition screening.
D)no screening because they already know their status.
24

A nasal spray containing adenovirus carrying a functional human CFTR gene is used to treat cystic fibrosis. This is an example of ____ gene therapy.
A)in situ
B)in vivo
C)ex vivo
D)vaccine
25

Gene therapy would have to "fix" ____ % of the cells in the liver to be effective.
A)1
B)5
C)10
D)50





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