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| 1. How does endospore formation contribute to Bacillus infections? Is the endospore considered a virulence factor? Why or why not? 2. Why are vaccines to clostridial toxins used instead of vaccines against the bacteria?3. Describe the epidemiology of classical diphtheria. How do these normal flora inhabitants suddenly cause disease?4. Why are diseases like tuberculosis considered to be major public health threats? What characteristics of the disease process perpetuate its spread? |