| Study Outline (See related pages)
- Transcriptional Regulation
- The phenomenon of enzyme adaptation is due to the synthesis of cellular proteins
- The lac operon encodes proteins that are involved in lactose metabolism
- The lac operon is regulated by a repressor protein
- Bacterial conjugation experiments provide evidence that the lacI gene encodes a repressor protein
- The lac operon is also regulated by an activator protein
- Further studies have revealed that the lac operon has three operator sites for the lac repressor
- The ara operon can be regulated positively or negatively by the same regulatory protein
- The trp operon is regulated by a repressor protein and also by attenuation
- Repressible operons usually encode anabolic enzymes, and inducible operons encode catabolic enzymes
- Translational and Posttranslational Regulation
- Repressor proteins and antisense RNA can inhibit translation
- Posttranslational regulation can occur via feedback inhibition and covalent modifications
- Gene Regulation In The Bacteriophage Life Cycle
- Phage l can follow a lytic or lysogenic life cycle
- During the lysogenic cycle, the cII/cIII complex activates expression of the l repressor
- The lytic cycle depends on the action of the cro protein
- Cellular proteases influence the choice between the lytic and lysogenic cycle
- The OR region provides a genetic switch between the lytic and lysogenic cycles
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