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| 1 | |
The average length of a gene in the unique sequences of the Drosophila genomic DNA is 8-9 kb. |
| | A) | True |
| | B) | False |
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| 2 | |
Fertilization takes place in Drosophila before the oocyte completes meiosis. |
| | A) | True |
| | B) | False |
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| 3 | |
In Drosophila, body segments first appear in the adult. |
| | A) | True |
| | B) | False |
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| 4 | |
In Drosophila, nerve cells arise from the ventral ectoderm. |
| | A) | True |
| | B) | False |
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| 5 | |
Drosophila compensates for the loss of telomeric DNA by adding repeats. |
| | A) | True |
| | B) | False |
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| 6 | |
Cell fate which is determined at least in part by neighboring cells exemplifies: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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| 7 | |
A chromosome which does not undergo recombination by virtue of its physical map exemplifies: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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| 8 | |
A nucleotide sequence which appears within the coding sequence of genes and regulates segment-specific tissues is: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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| 9 | |
A protein sequence which confers binding to segment-specific regulatory sequences within genes is: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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| 10 | |
A substance that defines different cell fates in a concentration-dependent manner is a: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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| 11 | |
P-element transposition is responsible for: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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| 12 | |
Mutations in the bithorax complex (BX-C) can result in: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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| 13 | |
Invagination of a band of midventral cells in the embryo is the first step of: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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| 14 | |
Control of developmental genes can be linked to reporter enzyme(s) by: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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| 15 | |
The transition from larva to adult occurs by: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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| 16 | |
The Pax6 gene in mice is homologous to the Drosophila gene: |
| | A) | sevenless |
| | B) | vestigial |
| | C) | ultrabithorax |
| | D) | eyeless |
| | E) | bride of sevenless |
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| 17 | |
Which of the following is not true of Drosophila development? |
| | A) | head arises from three segments |
| | B) | thorax arises from three segments |
| | C) | abdomen arises from eight segments |
| | D) | bicoid is a posterior mRNA |
| | E) | Nanos is a posterior protein |
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| 18 | |
Order the following classes of genes according to their hierarchy of function in early embryogenesis: A. pair rule genes, B. homeotic genes, C. gap genes, D. segment polarity genes, E. maternal genes |
| | A) | CDABE |
| | B) | ECDAB |
| | C) | BCADE |
| | D) | ACBED |
| | E) | DEABC |
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| 19 | |
Hybrid dysgenesis occurs in: |
| | A) | male P strains mated with female M strains |
| | B) | male M strains mated with female P strains |
| | C) | male M strains mated with female M strains |
| | D) | male P strains mated with female P strains |
| | E) | a & b |
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| 20 | |
Order the following stages in Drosophila embryogenesis: A. cellular blastoderm, B. syncitial blastoderm, C. gastrulation, D. fertilization, E. segmentation |
| | A) | DCBAE |
| | B) | ADCEB |
| | C) | DBACE |
| | D) | CDABE |
| | E) | DABCE |
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| 21 | |
Imaginal discs give rise to body segments in Drosophila development? |
| | A) | True |
| | B) | False |
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| 22 | |
In general, the developmental potential of cells becomes more and more restricted as development proceeds |
| | A) | True |
| | B) | False |
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| 23 | |
The bride of sevenless (boss) gene is cell autonomous. |
| | A) | True |
| | B) | False |
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| 24 | |
Pole cells are the first cells formed during embryonic development in Drosophila. |
| | A) | True |
| | B) | False |
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| 25 | |
The distribution of hunchback mRNA in the oocyte immediately prior to fertilization is a gradient from anterior (highest) to posterior (lowest). |
| | A) | True |
| | B) | False |
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| 26 | |
Transposase is encoded by: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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| 27 | |
Nuclei can respond directly to morphogen gradients in: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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| 28 | |
A clone of cells limited to a specific region but not necessarily a particular fate is: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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| 29 | |
Small groups of cells set aside in the embryo for future organogenesis are: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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| 30 | |
Signal transduction must take over for transmission of regulatory gradients after development of the embryonic: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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| 31 | |
Genes that determine certain patterns that are repeated in each segment are: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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| 32 | |
Genes which divide the body axis into rough, generalized regions are: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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| 33 | |
Genes that subdivide the developing embryo into two-segment units are: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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| 34 | |
The Antennapedia complex is an example of: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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| 35 | |
The distribution of bicoid is determined by: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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| 36 | |
To function as a balancer, a chromosome should: |
| | A) | have large rearrangements |
| | B) | be holocentric |
| | C) | have many repetitive sequences |
| | D) | a & b |
| | E) | b & c |
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| 37 | |
A cross of two individuals of a 'balanced lethal' strain yields: |
| | A) | 50% viable progeny homozygous for both markers |
| | B) | 25% viable progeny heterozygous for both markers |
| | C) | 50% viable progeny heterozygous for both markers |
| | D) | 25% viable progeny homozygous for both markers |
| | E) | none of the above |
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| 38 | |
What is the function of the lacZ structural gene associated with the P-element promoter in an enhancer trap? |
| | A) | confer Lac+ on transformants |
| | B) | select bacteria in plasmid rescue |
| | C) | report on neighboring regulatory sequences |
| | D) | all of the above |
| | E) | none of the above |
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| 39 | |
The 'Sander' model for body axis patterning described in this chapter has which of the following elements? |
| | A) | spatial gradients of mRNA |
| | B) | spatial gradients of proteins |
| | C) | spatial gradients of gene expression |
| | D) | a & b |
| | E) | all of the above |
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| 40 | |
Order the following genes according to their hierarchy of function in early embryogenesis: A. fushi tarazu, B. hedgehog, C. bicoid, D. hunchback, E. antennapedia |
| | A) | BCAED |
| | B) | ADEBC |
| | C) | DBAEC |
| | D) | EACBD |
| | E) | CDABE |
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