Site MapHelpFeedbackMultiple Choice Quiz
Multiple Choice Quiz
(See related pages)

1
The principal interest in developing the murine genetic model is the species' genetic similarity to humans.
A)True
B)False
2
Homology analysis identifies genes or regulatory DNA sequences that are similar in different species and are descended from a common ancestor.
A)True
B)False
3
The alpha and beta globin genes families of both mice and humans are found on different chromosomes and are considered to be unrelated.
A)True
B)False
4
The first differentiation events in mouse development begin in the 4-cell stage.
A)True
B)False
5
A primary oocyte begins the second meiotic division but will arrest at metaphase just before ovulation.
A)True
B)False
6
Cells which can adopt any developmental fate in the adult organism are:
A)syntenic
B)transgenic
C)totipotent
D)tetraparental
E)chimeric
7
Two or more loci which are linked are said to be:
A)syntenic
B)transgenic
C)totipotent
D)tetraparental
E)chimeric
8
The lineage of organisms derived from two independently fertilized embryos is said to be:
A)syntenic
B)transgenic
C)totipotent
D)tetraparental
E)chimeric
9
Organisms that arise from cells from two or more different origins are:
A)syntenic
B)transgenic
C)totipotent
D)tetraparental
E)chimeric
10
Organisms that have received heritable DNA by experimental manipulation are:
A)syntenic
B)transgenic
C)totipotent
D)tetraparental
E)chimeric
11
Cells which, in part, give rise to the mammalian placenta are contained in the:
A)blastocyst
B)inner cell mass
C)trophoectoderm
D)pronucleus
E)zona pellucida
12
The glycoprotein 'shell' surrounding the mammalian egg is the:
A)blastocyst
B)inner cell mass
C)trophoectoderm
D)pronucleus
E)zona pellucida
13
The zygote stage which is capable of implantation is known as the:
A)blastocyst
B)inner cell mass
C)trophoectoderm
D)pronucleus
E)zona pellucida
14
The three germ layers of ectoderm, mesoderm, and endoderm arise from the:
A)blastocyst
B)inner cell mass
C)trophoectoderm
D)pronucleus
E)zona pellucida
15
The haploid genome is contained in the:
A)blastocyst
B)inner cell mass
C)trophoectoderm
D)pronucleus
E)zona pellucida
16
Spermatogenesis in mammals includes:
A)differentiation
B)nuclear compaction
C)cytoplasmic expansion
D)a & b
E)all of the above
17
Female mice are born:
A)with a fixed number of oocytes
B)with oocytes arrested in meiosis II
C)at sexual maturity
D)a & b
E)all of the above
18
A typical mouse litter arises from which of the following?
A)8-10 fertilization events
B)8-10 oocytes
C)twinning
D)a & c
E)a & b
19
Which of the following is not characteristic of fertilization in mammals?
A)sperm binding releases proteases which digest away the zona pellucida
B)an action potential changes the egg cell membrane preventing further sperm cell entry
C)sperm storage
D)competing sperm bind to the zona pellucida
E)small fraction of sperm reach egg
20
After fertilization, the fertilized egg or zygote contains:
A)two pronuclei
B)two haploid sets of chromatids
C)maternal mitochondria
D)a & b
E)all of the above
21
When removed from the reproductive tract of the mother mouse, the post-implantation stage embryos can be manipulated experimentally and returned in a viable state to resume development in the uterus.
A)True
B)False
22
In both mice and humans genetic chimeras result from splitting of early cleavage division embryos which give rise to separate and genetically clonal individuals.
A)True
B)False
23
In transfected embryonic cells, approximately 10-3 to 10-5 of chromosomal integrations will replace the homologous gene or target DNA sequence.
A)True
B)False
24
Cultured mammalian cells grown in vitro frequently express transgene products differently from the same cells in vivo.
A)True
B)False
25
In Hox gene clusters, expression of the 5' gene is epistatic to the 3' genes.
A)True
B)False
26
Micromanipulation is used during introduction of DNA into embryos in the process of:
A)transfection
B)implantation
C)hatching
D)targeted mutagenesis
E)nuclear injection
27
Emergence from the zona pellucida is termed:
A)transfection
B)implantation
C)hatching
D)targeted mutagenesis
E)nuclear injection
28
Association of the blastocyst with the uterine wall is:
A)transfection
B)implantation
C)hatching
D)targeted mutagenesis
E)nuclear injection
29
Replacement of wild type genes with synthetic ones is the aim of:
A)transfection
B)implantation
C)hatching
D)targeted mutagenesis
E)nuclear injection
30
Uptake of DNA by cellular mechanisms occurs in the process of:
A)transfection
B)implantation
C)hatching
D)targeted mutagenesis
E)nuclear injection
31
Spatial development in the mouse is coordinated by members of the ________ family.
A)embryonic stem cell
B)cleavage stage
C)knockout construct
D)transgene
E)Hox gene
32
Totipotency changes along with:
A)embryonic stem cell
B)cleavage stage
C)knockout construct
D)transgene
E)Hox gene
33
An cell carrying a null transgenic allele is a:
A)embryonic stem cell
B)cleavage stage
C)knockout construct
D)transgene
E)Hox gene
34
Indefinite division without differentiation is a characteristic of:
A)embryonic stem cell
B)cleavage stage
C)knockout construct
D)transgene
E)Hox gene
35
Heritable DNA introduced by laboratory manipulation is an example of:
A)embryonic stem cell
B)cleavage stage
C)knockout construct
D)transgene
E)Hox gene
36
Transgenic vectors for the mouse can be constructed using which of the following components?
A)plasmid DNA.
B)retroviral flanking sequences
C)bacterial genes
D)a & b
E)all of the above
37
Embryonic nuclear injection can accomplish:
A)DNA addition to recipient genomes
B)translocations
C)deletions
D)analysis of recessive genes in the first transgenic generation
E)none of the above
38
Targeted mutagenesis:
A)requires random integration
B)requires retroviral flanking sequence DNA in the transgene construct
C)requires embryonic cell culture methods to select transformants that have undergone recombination
D)uses mutagens in vivo
E)depends on exogenously supplied DNA repair and recombination enzymes in mouse embryonic cells
39
You transfect SRY into genetically normal female cells and produce transgenic offspring. What might you expect to observe?
A)genetic males with female sexual characteristics
B)genetic males with male sexual characteristics
C)genetic females with female sexual characteristics
D)genetic females with male sexual characteristics
E)b & c
40
Which of the following techniques would help identify a transgenic cell line?
A)Northern analysis
B)Southern analysis
C)drug resistance phenotype
D)antibody to gene product
E)all of the above





To learn more about the book this website supports, please visit its Information Center.
(c)2004 McGraw-Hill Higher Education
Any use is subject to the Terms of Use and Privacy Notice.
McGraw-Hill Higher Education is one of the many fine businesses of The McGraw-Hill Companies.


Genetics: From Genes to GenomeOnline Learning Center

Home > Model Organisms 21 > Ref. Chapter E