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1
The passage of genetic material from parent to offspring is known as
A)replication.
B)transmission.
C)variation.
D)degradation.
E)information.
2
Which one of the following would only be found in a strand of DNA?
A)Uracil
B)Deoxyribose
C)Cytosine
D)Thymine
E)Guanine
3
Meselson and Stahl used density studies to prove DNA replication was
A)conservative.
B)liberal.
C)semiconservative.
D)dispersive.
E)conservative in eukaryotes and semiconservative in prokaryotes.
4
Which of the following statements regarding Avery, McCarty and MacLeod is incorrect?
A)They biochemically isolated macromolecules from Griffiths S-Strain bacteria.
B)Enzymes capable of digesting DNA, RNA and proteins were added to different samples to prevent any possible trace contaminants from altering their results.
C)Samples not containing DNA extract contained S strain bacteria
D)Avery, McCarty and MacLeod based their work on Griffiths.
E)Avery, McCarty and MacLeod concluded that DNA is the genetic material.
5
Arrange the following genetic terms in order of complexity from largest to smallest. I: chromosome : II nucleosome : III chromatin : IV nucleotide
A)i; iv; iii; ii
B)i; ii; iii; iv
C)iv; ii; iii; i
D)iii; ii; iv; i
E)iii; i; iv; ii
6
The covalent linkage that connects monomers in a nucleic acid macromolecule is most accurately referred to as a(n)
A)phosphodiester linkage.
B)ester linkage.
C)peptide linkage.
D)phosphoribose linkage.
E)glycosidic linkage.
7
Which of the following scientists was responsible for elucidating the structure of DNA using X-ray crystallography?
A)Watson
B)Franklin
C)Avery
D)Crick
E)Chargaff
8
One strand of a section of DNA reads:5' – TCGGACCTGAC – 3'. Which of the following would be the complementary strand?
A)5' – CAGTCCAGGCT – 3'
B)5' – UCGGACCUGAC – 3'
C)3' – AGCCTGGACTG – 5'
D)3' – GTCAGGTCCGA – 5'
E)5' – AGCCUGGACUG – 3'
9
Which of the following statements about DNA is correct?
A)The amount of adenine in double stranded DNA equals the amount of cytosine.
B)The amount of purines in double stranded DNA equals the amount of pyrimidines.
C)Thymine is a purine
D)The ratio of thymine to adenine is equal to the ratio of cytosine to guanine
E)All of these statements about DNA are correct.
10
True or False: Each DNA strand in a double helix contains all the information needed to make a new identical double helix.
A)True
B)False
11
Which one of the following statements about DNA replication is incorrect?
A)DNA replication is initiated at specific sites called origins of replication.
B)There are two replication forks per replication bubble.
C)DNA replication is bidirectional.
D)One daughter strand is synthesized in the direction of the replication fork, and the other daughter strand is synthesized in the direction away from the fork.
E)Okazaki fragments are synthesized from 3' to 5'
12
An enzyme called ________ is responsible for relieving the supercoiling of DNA caused by the unwinding of the double helix by ________.
A)helicase; topoisomerase
B)DNA polymerase III; DNA polymerase I
C)topoisomerase; helicase
D)DNA polymerase I; DNA polymerase III
E)ligase; primase
13
Which one of the following molecules would be needed for replication of DNA in E. coli?
A)Deoxyribonucleoside triphosphates
B)Single strand binding proteins
C)Ribonucleoside triphosphates
D)Primase
E)All of these molecules would be needed for replication of DNA in E. coli.
14
True or False: Because DNA replication begins with the synthesis of RNA primers, a completed double helix is actually a hybrid molecule of mostly DNA with some RNA.
A)True
B)False
15
Leading strand synthesis is ______________________ and lagging strand synthesis is ________________.
A)discontinuous : continuous
B)conservative : semiconservative
C)continuous : discontinuous
D)semiconservative : conservative
E)rapid : slow
16
Which one of the following statements most accurately describes proofreading?
A)Nucleotides are incorporated into the end of a newly made strand of DNA in the 3' to 5' direction.
B)Ribonucleotides are removed from Okazaki fragments and replaced with deoxyribonucleotides.
C)Nucleotides are removed from the end of a newly made strand of DNA in the 3' to 5' direction.
D)Nucleotides are incorporated into the end of a newly made strand of DNA in the 5' to 3' direction.
E)Nucleotides are removed from the end of a newly made strand of DNA in the 5' to 3' direction.
17
Which of the following enzymes is not used in leading strand synthesis? eukaryote?
A)Single strand binding proteins
B)DNA Polymerase
C)DNA Ligase
D)DNA Primase
E)Topoisomerase
18
Which of the following polymerases in prokaryotes and eukaryotes have the most similar function?
A)DNA Polymerase I and alpha polymerase
B)DNA polymerase II and epsilon polymerase
C)DNA polymerase III and kappa polymerase
D)DNA polymerase IV and sigma polymerase
E)DNA polymerase V and delta polymerse
19
True or False: There is a small amount of single stranded RNA found at the end of a linear chromosome.
A)True
B)False
20
Which one of the following statements about telomerase is correct?
A)Telomerase utilizes recycled fragments of DNA to act as template molecules for replication of chromosome ends.
B)Telomerase consists of a protein component and an RNA component complement to the DNA telomere.
C)All cells in the human body have the same amount of telomerase activity.
D)As cells approach senescence, their telomerase activity increases.
E)In 90% of all human cancers, telomerase activity is non-existent.





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