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| 1 | |
When a person develops Paget's disease, for unknown reasons the collagen fibers in the bone matrix run randomly in all directions. In addition, the amount of trabecular bone decreases. What symptoms would you expect to observe? |
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| 2 | |
When closure of the epiphyseal plate occurs, the cartilage of the plate is replaced by bone. Does this occur from the epiphyseal side of the plate or the diaphyseal side? |
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| 3 | |
Assume that two patients have identical breaks in the femur (thighbone). If one is bedridden and the other has a walking cast, which patient's fracture heals faster? Explain. |
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| 4 | |
Explain why running helps prevent osteoporosis in the elderly. Does the benefit include all bones or mainly those of the legs and spine? |
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| 5 | |
Astronauts can experience a dramatic decrease in bone density while in a weightless environment. Explain how this happens, and suggest a way to slow the loss of bone tissue. |
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| 6 | |
Would a patient suffering from kidney failure be more likely to develop osteomalacia or osteoporosis? Explain. |
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| 7 | |
In some cultures eunuchs were responsible for guarding harems, which are the collective wives of one male. Eunuchs are males who, as boys, were castrated. Castration removes the testes, the major site of testosterone production in males. Because testosterone is responsible for the sex drive in males, the reason for castration is obvious. As a side effect of this procedure, the eunuchs grew to above-normal heights. Can you explain why? |
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| 8 | |
When a long bone is broken, blood vessels at the fracture line are severed. The formation of blood clots stops the bleeding. Within a few days bone tissue on both sides of the fracture site dies. The bone only dies back a certain distance from the fracture line, however. Explain. |
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| 9 | |
A patient has hyperparathyroidism because of a tumor in the parathyroid gland that produces excessive amounts of PTH. What effect does this hormone have on bone? Would administration of large doses of vitamin D help the situation? Explain. |
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