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What do the Holliday model and the double stranded break model have in common? |
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2 | |
What is the major drawback to the Holliday model of recombination? |
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3 | |
Describe DNA gap repair synthesis. |
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4 | |
State three functions of proteins in homologous recombination. |
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5 | |
Why is sister chromatid exchange not considered to be a form of recombination? |
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6 | |
Which types of recombination are most likely to result in gene conversion? |
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7 | |
With 500 variable domains, 12 diversity domains, 4 joining domains, and one constant domain, how many possible different immunoglobulin heavy chains can be constructed? |
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8 | |
Animal cloning is now possible by placing the nucleus of a somatic cell into an enucleated oocyte. Would you expect B cells of the immune system to be good somatic cells to use for this process? Why or why not? |
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9 | |
Would you expect a hybrid between a corn stain expressing the Ac element in the germline, but containing no Ds elements, and a strain containing many Ds elements but no Ac elements to be highly fertile, moderately fertile, or infertile? Why? |
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10 | |
A true breeding strain of petunias with purple flowers is crossed to a true breeding strain with white flowers. Most of the offspring have purple flowers but in one plant the flowers are mostly white with purple flecks and occasionally large purple sectors. What might explain this situation? |
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11 | |
Transposition involves creation of direct repeats from the original target sequence. What evidence might be left behind after excision of a transposon? |
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12 | |
Would you expect the Alu sequence to have become so prevalent in the human genome if it had been a replicative transposon? |
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13 | |
In Drosophila, a complete transposon known as the P element exists stably in many copies in strains known as P strains. M strain flies have no P elements. When a male of a P strain is mated to an M strain female, offspring exhibit hybrid dysgenesis, a syndrome of many mutations and abnormalities. The reciprocal cross (P strain female x M strain male) does not display hybrid dysgenesis. How might you explain this situation? |
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14 | |
How might transposon tagging be used to tag genes on chromosomes other than the X? |
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