Chapter 10 Quiz 1

Chapter 10 Quiz 1

Chapter 10 Quiz 1
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1		Research has shown that L-ibuprofen is an effective pain reliever but D-ibuprofen is not at all effective. What generalization can be drawn from this information?
			A)	Only the L-isomer can be microencapsulated or used as an implant. This difference in packaging is responsible for the difference in the biochemical activity.
			B)	These two structural isomers behave exactly the same in biological systems, but only L-ibuprofen blocks the pain signal.
			C)	The difference in behavior illustrates the molecular specificity of a substrate for its binding site.
			D)	Biochemical activity is related to the molecular weight of a drug.


2		This is the condensed structural formula for aspirin, the most widely used drug in the world. What is its molar mass?
			A)	104 g/mol
			B)	168 g/mol
			C)	180 g/mol
			D)	182 g/mol


3		Molecules as diverse as cholesterol, sex hormones, and cortisone all contain common structural elements associated with steroids. Which structural formula represents the common structure?
			A)
			B)
			C)
			D)


4		What is the "Fast-Track" program of the FDA?
			A)	It is a program to bring promising drugs to the market more quickly.
			B)	It is a program to eliminate clinical testing of new drugs.
			C)	It is a program to move from a pioneer drug to generic drugs in less than the usual 20 years.
			D)	It is a program to make untested drugs available to doctors under strict patient supervision.


5		Thalidomide, a sedative originally introduced in Europe in 1956, was later discovered to be a potent teratogen. If that is the case, why are doctors now again interested in this drug?
			A)	There is new evidence that Thalidomide has therapeutic usefulness for the treatment of cancer, blindness, and/or AIDS.
			B)	Thalidomide is now sold as a supplement and used by athletes to increase endurance and enhance muscular strength.
			C)	Adequate testing of this drug has now taken place, so the U.S. Food and Drug Administration has approved its use as a sedative.
			D)	Most of the teratogenic effects seen from use of Thalidomide were observed in Europe, and would not be seen if used in the U.S.


6		This structure shows a methyl group attached to which other functional group?
			A)	aldehyde
			B)	carboxylic acid
			C)	alcohol
			D)	ketone


7		If plane-polarized light is passed through a solution containing certain dissolved compounds, the plane of the plane-polarized light is rotated. This is an experimental test for the presence of
			A)	optically active isomers.
			B)	geometric isomers.
			C)	structural isomers.
			D)	biopolymers.


8		Which statement concerning drug activity is the best generalization?
			A)	The drug that has the most polar and nonpolar functional groups will be the most effective.
			B)	The drug that best fits the receptor site has the potential to have the highest therapeutic activity.
			C)	Any drug isolated from natural products is always more active than its synthetic equivalent.
			D)	The larger the molecular mass of the drug, the more effective it will be in drug therapy.


9		Which structure is classed as an aldehyde?
			A)
			B)
			C)
			D)


10		Here is the structure for the common drug ibuprofen. How many single bonds and how many double bonds are represented by this shorthand structural formula?
			A)	29 single, 4 double
			B)	25 single, 4 double
			C)	18 single, 3 double
			D)	10 single, 3 double


11		This is the carbon skeleton for one of the structural isomers of pentane, C₅H₁₂. (All hydrogen atoms and all bonds from carbons to hydrogen have been omitted for clarity.) Which structure is just a different paper-and-pencil representation of the same isomer?
			A)
			B)
			C)
			D)


12		Which of these compounds can exist in chiral forms?
			A)
			B)
			C)
			D)


13		Which incorrectly pairs a drug and its physiological function?
			A)	quinine, historical anti-malarial
			B)	demerol, analgesic
			C)	progestin, body-building
			D)	ibuprofen, anti-inflammatory


14		Which statement is true concerning organic chemistry, the chemistry of carbon?
			A)	Carbon primarily forms bonds to other carbons and hydrogen.
			B)	Molecules that contain a specific functional group generally have similar chemical and physical properties.
			C)	Propane has several isomers because three carbons can be arranged in several ways.
			D)	Statements A and B are both true concerning the chemistry of carbon.


15		Which organic functional group does not contain a C=O portion?
			A)	ester
			B)	ether
			C)	amide
			D)	ketone

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