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Short Answer Quiz
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1

What factors may reduce concordance rates in identical and fraternal twins?
2

State the four common features of an autosomal recessive pattern of inheritance.
3

What does it mean to say that an autosomal recessive trait can "skip generations"?
4

Under what circumstances might an individual affected with an autosomal dominant trait not have an affected parent?
5

Prior to the advent of modern medical treatments, individuals with hemophilia A rarely survived to reproductive age. How might this impact the frequency with which women are affected by hemophilia A?
6

List two possible concerns about genetic testing.
7

How can prions cause both infectious and inherited disease?
8

What is the difference between an oncogene and a proto-oncogene?
9

List two classes of genes that can become oncogenic if mutated.
10

What is the Philadelphia chromosome?
11

State the two-hit model of tumorigenesis.
12

What is the major role of the p53 protein?
13

In addition to specific mutations that inactivate tumor suppressor proteins or prevent normal expression of the gene, tumor suppressor function can be lost in two different ways. What are they?
14

Identify three classes of genes that cause a predisposition to development of somatic cancer when mutant.





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