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Short Answer Quiz
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1

Describe physical mapping.
2

Describe FISH.
3

What is an advantage of using molecular markers rather than known genes?
4

Name the two types of molecular markers commonly used in DNA fingerprinting studies.
5

Diploid individuals typically have how many copies of a particular AFLP?
6

Are these markers linked? How can you tell?
7

Does it matter what genotype you use for the last cross?
8

RFLP mapping typically involves generation of pedigrees in which a large number of RFLPs are assorting, rather than single mapping crosses. An unknown gene can be mapped near an RFLP by comparing the phenotype caused by variants of that gene with a large number of RFLPs and calculating LOD scores for each RFLP. Given the following results, if RFLPs 1-5 are on chromosome 1, 6-8 are on chromosome 2, and 9-11 are on chromosome 3, what can you say about the probable location of the unknown gene?
RFLP1234567891011
LOD score0.151.41.00.571.62.23.23.52.30.90.6
9

There may be thousands of sites that contain the (CA)n microsatellite repeat. How can scientists focus on only one of these sites?
10

Some forms of genetic testing rely on linkage between a marker such as a microsatellite and a gene. Give at least one drawback to use of this technique.
11

Name two techniques that can be used to isolate individual chromosomes.
12

Describe a chromosome-specific library.
13

Once a contig has been produced, what is the first step toward use of the contig in physical mapping experiments?
14

Why would a YAC need to have origins of replication for both yeast and bacteria?
15

Why was the first main goal of the Human Genome Project to obtain a genetic linkage map of the human genome?
16

List at least three potentially beneficial uses of the information gathered by the Human Genome Project.





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